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首页> 外文期刊>Journal of women’s health >Predictors of Depressive Relapse in Women Undergoing Infertility Treatment
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Predictors of Depressive Relapse in Women Undergoing Infertility Treatment

机译：不育症治疗妇女抑郁复发的预测因素

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Background: Despite high prevalence rates among women of mood disorders and of infertility, there is a paucity of systematic data to inform the treatment of women at risk for psychiatric morbidity in the context of assisted reproductive technologies (ART). The objective was to delineate predictors of depressive relapse in women with histories of mood disorders during ART, including the role of psychotropic medication continuation. Methods: This was a prospective observational study of women undergoing ART with past diagnoses of major depressive disorder (MDD) or bipolar depression. For 6-months, follow-up included assessments of mood, perceived stress, and partner support. A subsample participated in biomarker collection. Depressive relapse was confirmed using Mini-International Neuropsychiatric Interview. Results:N=38 were evaluable. Participants with MDD (N=25) experienced a depressive relapse rate of 44.0%. Relapse rates among antidepressant maintainers (N=15; relapse rate=40.0%) and antidepressant discontinuers (N=10; relapse rate=50.0%) were not significantly different. Among participants with bipolar disorder (N=13), the overall relapse rate was 30.8%. Among psychotropic medication maintainers (N=10), 40.0% relapsed, and among discontinuers (N=3), none relapsed. Scores on the Perceived Stress Scale correlated with relapse risk (odds ratio [OR]=1.17, 95% confidence interval [CI]: 1.08-1.26, p=0.0065). C-reactive protein was associated with relapse (OR=1.92, 95% CI: 1.43-2.55, p0.0001); blood cortisol and interleukin-6 were not. Conclusions: Risk of depressive relapse among women undergoing ART is considerable. Medication continuation does not adequately confer relapse prevention. Stress and inflammation appear to contribute to risk of relapse. Additional strategies to mitigate depressive relapse in at-risk women undergoing ART are needed.
机译：背景技术：尽管情绪障碍妇女和不孕症的患病率高，但缺乏系统数据，以便在辅助生殖技术（艺术品）的背景下，为精神病发病率的危险提供通知妇女的治疗。目标是在艺术期间描绘患有情绪障碍历史的妇女抑郁复发的预测因子，包括精神药物延续的作用。方法：这是对经历艺术的妇女过去诊断术后主要抑郁症（MDD）或双相抑郁症的前瞻性观察研究。 6个月，随访包括对情绪，感知压力和合作伙伴支持的评估。 Aubsample参加了生物标志物收集。使用迷你国际神经精神科专访确认抑郁复发。结果：n = 38是可评估的。 MDD（n = 25）的参与者经历了44.0％的抑郁复发率。抗抑郁症维护者中的复发率（n = 15;复发率= 40.0％）和抗抑郁的异诺埃（n = 10;复发率= 50.0％）没有显着差异。与双相障碍（N = 13）的参与者中，整体复发率为30.8％。在精神药物维护者（n = 10）中，复发40.0％，在停止介导者（n = 3）中，没有复发。感知压力比分与复发风险相关（差距[或] = 1.17,95％置信区间[CI]：1.08-1.26，P = 0.0065）。 C-反应蛋白与复发相关（或= 1.92,95％CI：1.43-2.55，P <0.0001）;血皮质醇和白细胞介素-6不是。结论：接受艺术妇女抑郁复发的风险是相当大的。药物延续没有充分赋予复发预防。压力和炎症似乎有助于复发的风险。需要减轻患有艺术的风险妇女抑郁复发的额外策略。

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