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首页> 外文期刊>Journal of women’s health >Sleep Duration and Risk of Liver Cancer in Postmenopausal Women: The Women's Health Initiative Study
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Sleep Duration and Risk of Liver Cancer in Postmenopausal Women: The Women's Health Initiative Study

机译：绝经后妇女肝癌的睡眠持续时间和风险：女性健康倡议研究

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Background: Sleep duration has been associated with nonalcoholic fatty liver disease, but its association with liver cancer remains unknown. Material and Methods: In the prospective Women's Health Initiative Study, 139,368 postmenopausal women reported sleep habits at baseline (1993-1998). We ascertained 175 incident liver cancer cases during an average 13.8 years of follow-up through August 2014. We used multivariable Cox proportional hazard regression models to estimate a hazard ratio (HR) and its 95% confidence interval (95% CI) for risk of liver cancer in association with nocturnal sleep duration. Results: Compared to women reporting 6-8 hours of sleep, the HR for liver cancer was 1.94 (95% CI 1.07-3.53) for women reporting 9 hours of sleep. Among the obese women, the HR associated with 9 hours of sleep was 3.18 (95% CI 1.84-8.60). The HR was 0.93 (95% CI 0.34-2.53) among nonobese women (p value for interaction=0.18). Short sleep duration (5 hours) was not associated with liver cancer risk. Conclusion: Long sleep duration was associated with a moderate increase in liver cancer risk in obese postmenopausal women in the United States. Larger study is needed to confirm our observation on effect modification by adiposity status.
机译：背景：睡眠持续时间已经与非酒精性脂肪肝病有关，但其与肝癌的关系仍然未知。材料和方法：在预期妇女的健康倡议研究中，139,368名绝经后妇女报告了基线的睡眠习惯（1993-1998）。我们在2014年8月的平均随访期间确定了175名入射肝癌病例。我们使用多变量的Cox比例危险回归模型来估计风险的危险比（HR）及其95％的置信区间（95％CI）肝癌与夜间睡眠持续时间相关联。结果：与报告6-8小时睡眠的女性相比，肝癌的人力资源为1.94（95％CI 1.07-3.53），为睡眠9小时。在肥胖女性中，与9小时睡眠相关的人力资源为3.18（95％CI 1.84-8.60）。在非同源女性中，HR为0.93（95％CI 0.34-2.53）（用于相互作用的P值= 0.18）。睡眠时间短（5小时）与肝癌风险无关。结论：长期睡眠持续时间与美国肥胖绝经妇女在美国中肝癌风险中度增长的相关性。需要更大的研究来通过肥胖状态确认我们对效果修改的观察。

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