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首页> 外文期刊>Journal of cellular biochemistry. >Identification of messenger and long noncoding RNAs associated with gallbladder cancer via gene expression profile analysis
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Identification of messenger and long noncoding RNAs associated with gallbladder cancer via gene expression profile analysis

机译：通过基因表达谱分析识别与胆囊癌相关的信使和长的非致rNA

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Abstract The present study aimed to investigate the long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs) involved in the progression of gallbladder cancer and explore the potential physiopathologic mechanisms of gallbladder cancer in terms of competing endogenous RNAs (ceRNAs). The original lncRNA and mRNA expression profile data (nine gallbladder cancer tissues samples and nine normal gallbladder samples) in GSE76633 was downloaded from the Gene Expression Omnibus database. Differentially expressed mRNAs and lncRNAs between gallbladder cancer tissue and normal control were selected and the pathways in which they are involved were analyzed using bioinformatics analyses. MicroRNAs (miRNAs) were also predicted based on the differentially expressed mRNAs. Finally, the co‐expression relation between lncRNA and mRNA was analyzed and the ceRNA network was constructed by combining the lncRNA‐miRNA, miRNA‐mRNA, and lncRNA‐mRNA pairs. Overall, 373 significantly differentially expressed mRNAs and 47 lncRNAs were identified between cancer and normal tissue samples. The upregulated genes were significantly enriched in the extracellular matrix (ECM)‐receptor interaction pathway, while the downregulated genes were involved in the complement and coagulation cascades. Altogether, 128 co‐expression relations between lncRNA and mRNA were obtained. In addition, 196 miRNA‐mRNA regulatory relations and 145 miRNA‐lncRNA relation pairs were predicted. Finally, the lncRNA‐miRNA‐gene ceRNA network was constructed by combining the three types of relation pairs, such as XLOC_011309‐miR‐548c‐3p‐ SPOCK1 and XLOC_012588‐miR‐765‐ CEACAM6 . mRNAs and lncRNAs may be involved in gallbladder cancer progression via ECM‐receptor interaction pathways and the complement and coagulation cascades. Moreover, ceRNAs such as XLOC_011309‐miR‐548c‐3p‐ SPOCK1 and XLOC_012588‐miR‐765‐ CEACAM6 can also be implicated in the pathogenesis of gallbladder cancer.
机译：摘要目前的研究旨在研究涉及胆囊癌进展的长度非编码RNA（LNCRNA）和信使RNA（MRNA），并在竞争内源性RNA（CERNAS）方面探讨胆囊癌的潜在物理病理学机制。从基因表达Omnibus数据库下载GSE76633中的原始LNCRNA和mRNA表达谱数据（九个胆囊癌组织样品和九正常胆囊样品）。选择胆囊癌组织和正常对照之间的差异表达MRNA和LNCRNA，并使用生物信息学分析分析涉及它们的途径。还基于差异表达的MRNA预测MicroRNAS（miRNA）。最后，分析了LNCRNA和mRNA之间的共表达关系，并通过组合LNCRNA-miRNA，miRNA-mRNA和LNCRNA-mRNA对构建Cerna网络。总体而言，373显着表达了癌症和正常组织样品之间的MRNA和47个LNCRNA。在细胞外基质（ECM）的相互作用途径中显着富集上调基因，而下调基因涉及补体和凝血级联。完全，获得了LNCRNA和mRNA之间的128个共表达关系。此外，预测了196个miRNA-mRNA调节关系和145 miRNA-LNCRNA关系对。最后，通过组合三种类型的关系对构建LNCRNA-miRNA-基因Cerna网络，例如XLOC_011309-MIR-548C-3P-SPOCK1和XLOC_012588-MIR-765- CEACAM6。 MRNA和LNCRNA可以通过ECM受体相互作用途径和补体和凝固级联涉及胆囊癌进展。此外，诸如XLOC_011309-MIR-548C-3P-SPOCK1和XLOC_012588-MIR-765- CEACAM6的CERNA也可以涉及胆囊癌的发病机制。

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