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首页> 外文期刊>American Journal of Perinatology >The risk for preterm labor in women receiving 17 alpha-hydroxyprogesterone caproate prophylaxis for preterm birth prevention.
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The risk for preterm labor in women receiving 17 alpha-hydroxyprogesterone caproate prophylaxis for preterm birth prevention.

机译：接受17α-羟孕酮己酸酯预防为早产预防的妇女发生早产的风险。

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摘要

We sought to identify maternal or clinical characteristics of women likely to develop preterm labor (PTL) at <34 weeks' gestation while receiving 17 alpha-hydroxyprogesterone caproate (17P) prophylaxis. Current singleton gestations with prior preterm delivery enrolled for outpatient 17P administration at <27 weeks' gestation were identified ( N = 1177). Maternal and clinical characteristics were compared between women hospitalized and diagnosed with PTL at <34 weeks' gestation (PTL group, N = 270) and those without PTL (No PTL group, N = 660). PTL at <34 weeks' gestation occurred in 270/1177 (22.9%) of patients receiving 17P prophylaxis (mean gestational age at diagnosis was 28.3 +/- 4.0 weeks). Recurrent preterm delivery occurred in 73.3% of women with PTL at <34 weeks. Maternal age, marital status, race, tobacco use, cerclage, gestational age at start of 17P, and Medicaid status were similar between the groups. Women developing PTL at <34 weeks were more likely to have >1 prior preterm delivery than those without PTL (35.2% versus 25.9%, P = 0.006, odds ratio [95% confidence interval] 1.5 [1.1, 2.1]). Women receiving 17P prophylaxis remain at increased risk for PTL and preterm birth. Patient education and surveillance for PTL symptoms may be warranted in women with a history of more than one prior preterm delivery.
机译：我们试图确定在接受17α-羟孕酮（17P）预防的情况下，在怀孕＜34周时可能发展为早产（PTL）的女性的母亲或临床特征。确定了当前的单胎妊娠和早产分娩，这些妊娠在小于27周的妊娠中接受了门诊17P给药（N = 1177）。比较住院和诊断为妊娠<34周时有PTL的妇女（PTL组，N = 270）和没有PTL的妇女（无PTL组，N = 660）的产妇和临床特征。接受17P预防的患者中，<34周妊娠时发生PTL（270/1177）（22.9％）（诊断时的平均孕周为28.3 +/- 4.0周）。 <34周时，PTL妇女中有73.3％的妇女再次发生早产。两组之间的孕产妇年龄，婚姻状况，种族，烟草使用，环扎，孕周开始时的胎龄和医疗补助状况相似。与没有PTL的女性相比，在<34周发展PTL的女性更可能早产> 1（35.2％对25.9％，P = 0.006，优势比[95％置信区间] 1.5 [1.1，2.1]）。接受17P预防的妇女仍然存在PTL和早产的风险增加。有超过一个早产史的女性可能需要对PTL症状进行患者教育和监视。

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