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首页> 外文期刊>Biotechnology Advances: An International Review Journal >Silk sericin: A versatile material for tissue engineering and drug delivery
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Silk sericin: A versatile material for tissue engineering and drug delivery

机译：丝胶蛋白：用于组织工程和药物输送的多功能材料

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Sericin is an inexpensive glycoprotein obtained as a by-product in the silk industry. Its variable amino acid composition and diverse functional groups confer upon it attractive bioactive properties, which are particularly interesting for biomedical applications. Because of its antioxidant character, moisturizing ability, and mitogenic effect on mammalian cells, sericin is useful in cell culture and tissue engineering. Its positive effects on keratinocytes and fibroblasts have led to the development of sericin-based biomaterials for skin tissue repair, mainly as wound dressings. Additionally, sericin can be used for bone tissue engineering owing to its ability to induce nucleation of bone-like hydroxyapatite. Stable silk sericin biomaterials, such as films, sponges, and hydrogels, are prepared by cross-linking, ethanol precipitation, or blending with other polymers. Sericin may also be employed for drug delivery because its chemical reactivity and pH-responsiveness facilitate the fabrication of nano- and microparticles, hydrogels, and conjugated molecules, improving the bioactivity of drugs. Here, we summarized the recent advancements in the study of silk sericin for application in tissue engineering and drug delivery. (C) 2015 Elsevier Inc. All rights reserved.
机译：丝胶蛋白是在丝绸工业中作为副产物获得的廉价糖蛋白。其可变的氨基酸组成和不同的官能团赋予其有吸引力的生物活性，这对于生物医学应用而言尤其令人感兴趣。由于其抗氧化特性，保湿能力和对哺乳动物细胞的促有丝分裂作用，丝胶蛋白可用于细胞培养和组织工程。它对角质形成细胞和成纤维细胞的积极作用已导致开发基于丝胶蛋白的生物材料，用于修复皮肤组织，主要是作为伤口敷料。另外，由于丝胶蛋白具有诱导骨状羟基磷灰石成核的能力，因此可以用于骨组织工程。稳定的丝胶蛋白生物材料，例如薄膜，海绵和水凝胶，是通过交联，乙醇沉淀或与其他聚合物共混而制备的。丝胶蛋白也可以用于药物递送，因为其化学反应性和pH响应性促进了纳米和微粒，水凝胶和结合分子的制造，从而改善了药物的生物活性。在这里，我们总结了丝绢胶蛋白在组织工程和药物输送中的研究进展。 （C）2015 Elsevier Inc.保留所有权利。

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