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首页> 外文期刊>American Journal of Obstetrics and Gynecology >Antiemetic medications in pregnancy: A prospective investigation of obstetric and neurobehavioral outcomes
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Antiemetic medications in pregnancy: A prospective investigation of obstetric and neurobehavioral outcomes

机译：妊娠止吐药：对产科和神经行为预后的前瞻性研究

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Objective The study goal was to examine the impact of commonly prescribed antiemetic medications in pregnancy on neurobehavioral and obstetric outcomes. Study Design Five hundred thirty-three women accounting for 550 live births (17 multiple gestations) enrolled before 16 weeks' gestation participating in an observational longitudinal study of stress and pharmacologic exposure in pregnancy at Emory Women's Mental Health Program were included in this study. Maternal report of exposure to medications was documented by weeks of use. Obstetric and neonatal data were obtained from medical records. The Neonatal Behavioral Assessment Scale was completed by certified raters at age 7 days. The Child Behavior Checklist (CBCL) was completed by the mother between 17 and 66 months of age. Comparison of groups was conducted using χ2 and Wilcoxon rank-sum tests. Spearman correlation analysis was used for CBCL percentile scores to evaluate duration of exposure. Results The exposed group (n = 143) was comprised of children whose mothers received promethazine or ondansetron during pregnancy. Unexposed children (n = 407) were used for comparison. Neonatal Behavioral Assessment Scale data 7 days (range, 2-77) was available on 345 infants (exposed n = 102; unexposed n = 243), and a total of 247 CBCLs (exposed n = 51; unexposed n = 196) at 29 (range, 17-66) months of age. No significant differences were seen using Neonatal Behavioral Assessment Scale and CBCL. Statistically significant differences were seen in gestational age at delivery (0.3 weeks) and birthweight (110 g). Conclusion No clinically significant adverse neurobehavioral effects or obstetric outcomes were identified. This is reassuring as promethazine and ondansetron are commonly prescribed during pregnancy.
机译：目的研究目的是研究妊娠期常用止吐药对神经行为和产科结局的影响。研究设计本研究纳入了543名在怀孕16周之前入围550例活产（17次多胎）的妇女，参加了Emory Women's Mental Health Program的妊娠期压力和药物暴露的观察性纵向研究。母婴使用药物的报告已记录使用数周。产科和新生儿数据来自医疗记录。新生儿行为评估量表由认证评估者在7天时完成。儿童行为清单（CBCL）由17至66个月大的母亲填写。使用χ2和Wilcoxon秩和检验进行组比较。 Spearman相关分析用于CBCL百分分数，以评估暴露时间。结果暴露组（n = 143）由母亲在孕期接受异丙嗪或恩丹西酮的儿童组成。未接触的儿童（n = 407）用于比较。 345位婴儿（n = 102; n = 243未暴露）和247位CBCL（n = 51; n = 196）共7天（2-77）新生儿行为评估量表数据可供使用。 （17-66）个月大。使用新生儿行为评估量表和CBCL没有发现显着差异。分娩时的胎龄（0.3周）和出生体重（110 g）在统计学上有显着差异。结论未发现临床上明显的不良神经行为或产科预后不良。由于在怀孕期间通常开处方异丙嗪和恩丹西酮，这令人放心。

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