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首页> 外文期刊>American journal of psychiatry >Neuroimaging the infant: the application of modern neurobiological methods to the neurodevelopmental hypothesis of schizophrenia.
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Neuroimaging the infant: the application of modern neurobiological methods to the neurodevelopmental hypothesis of schizophrenia.

机译：对婴儿进行神经成像：将现代神经生物学方法应用于精神分裂症的神经发育假说。

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摘要

In the study reported in this issue, Gilmore et al. (1) demonstrated that neuroimaging the brain in infants at risk for schizophrenia is feasible. This work may lead to advances in understanding the neurobiological underpinnings of the neurodevelopmental hypothesis of schizophrenia.This hypothesis proposes that the onset of psychotic symptoms is the end result of decades of interaction between genetic and environmental factors. Two critical windows have been suggested: a fetal and early infancy period, during which vulnerability is established, and a later, often adolescent or young adult period, during which conversion from vulnerability to psychosis occurs. Brain changes during the perinatal window are not deterministic in that the majority of individuals born with vulnerability will never develop the full clinical disorder. Similarly, in less vulnerable individuals, genetic and environmental factors present during the second critical window appear to have minimal effect and are not associated with an increased risk for psychosis.
机译：在本期报道的研究中，Gilmore等人。 （1）证明对患有精神分裂症风险的婴儿进行脑部神经成像是可行的。这项工作可能会导致人们对精神分裂症神经发育假说的神经生物学基础的理解得到进一步发展。该假说表明，精神病症状的发作是遗传和环境因素之间数十年相互作用的最终结果。已经提出了两个关键的窗口：在胎儿和婴儿早期阶段，在此期间建立了脆弱性;以及在以后的阶段，通常是青春期或年轻的成年时期，在此期间，发生了从脆弱性到精神病的转变。围产期窗口期间的脑部变化不是确定性的，因为大多数具有脆弱性的人将永远不会发展出完整的临床疾病。同样，在弱势人群中，第二个关键窗口中出现的遗传和环境因素似乎影响最小，并且与精神病风险增加无关。

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