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首页> 外文期刊>Allergy >The association of asthma, atopy and lung function with hormone replacement therapy and surgical cessation of menstruation in a population-based sample of English women.
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The association of asthma, atopy and lung function with hormone replacement therapy and surgical cessation of menstruation in a population-based sample of English women.

机译：在以人群为基础的英国女性样本中，哮喘，特应性和肺功能与激素替代疗法和月经手术停止的关系。

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BACKGROUND: Gynaecological surgery that may lead to cessation of menstruation is a major indication for the use of hormone replacement therapy (HRT) which in turn has been associated with asthma. METHODS: Information on asthma-like symptoms, lung function and immunoglobulin E (IgE) sensitization to house dust mite (HDM) and on menstrual status and use of HRT was collected from 3724 women aged between 35 and 64 years living in England. Association of health outcomes with use of HRT and with surgery resulting in cessation of menstruation was examined in multivariable models. RESULTS: Over a third of women who had ever used HRT had undergone surgery resulting in cessation of menstruation. Current use of HRT was associated with frequent wheeze, particularly in lean women [body mass index (BMI) < 25; odds ratio (OR) 1.90; 95% confidence interval (CI) 1.17-3.05; BMI 25+; OR 1.02; 95% CI 0.69-1.51]. Wheeze was associated with the reporting of menstrual cessation that was due to surgery even if women denied ever using HRT (OR 1.55; 95% CI 1.09-2.20). There was some evidence that HRT use was associated with airway obstruction in leaner women but little evidence that it was associated with IgE sensitization to HDM. CONCLUSIONS: In this cross-sectional study use of HRT was associated with asthma-like symptoms, particularly in those who have lower BMI. A substantial proportion of women whose periods have stopped because of surgery use HRT but this does not fully explain their increased morbidity.
机译：背景：可能导致月经停止的妇科手术是使用激素替代疗法（HRT）的主要指征，而激素替代疗法又与哮喘有关。方法：收集了来自英格兰的3724名年龄在35至64岁之间的女性的信息，这些信息包括哮喘样症状，肺功能和免疫球蛋白E（IgE）对屋尘螨（HDM）的致敏性以及月经状况和HRT的使用情况。在多变量模型中检查了健康结局与使用HRT以及导致月经停止的手术的相关性。结果：曾经使用过HRT的妇女中有三分之一以上接受了手术，导致月经停止。当前使用HRT与频繁的喘息相关，尤其是在瘦女人中[身体质量指数（BMI）<25;比值比（OR）1.90; 95％置信区间（CI）1.17-3.05; BMI 25岁以上;或1.02; 95％CI 0.69-1.51]。即使女性拒绝使用HRT，喘息也与由于手术导致的月经停止有关（OR 1.55; 95％CI 1.09-2.20）。有一些证据表明，在苗条的女性中使用HRT与气道阻塞有关，但几乎没有证据表明它与IgE对HDM的敏感性有关。结论：在这项横断面研究中，HRT的使用与哮喘样症状有关，特别是在BMI较低的患者中。由于手术而停止手术的妇女中，有相当大的一部分使用HRT，但这不能完全解释其发病率的增加。

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