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首页> 外文期刊>Allergy >Recurrent wheezing after respiratory syncytial virus or non-respiratory syncytial virus bronchiolitis in infancy: a 3-year follow-up.
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Recurrent wheezing after respiratory syncytial virus or non-respiratory syncytial virus bronchiolitis in infancy: a 3-year follow-up.

机译：婴儿时期出现呼吸道合胞病毒或非呼吸道合胞病毒细支气管炎后反复喘息：3年随访。

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BACKGROUND: Recent studies have suggested that rhinovirus-associated early wheezing is a greater risk factor for development of recurrent wheezing in children than is early wheezing associated with respiratory syncytial virus (RSV). We determined the development of recurrent wheezing in young children within 3 years after hospitalization for RSV or non-RSV bronchiolitis. METHODS: We identified retrospectively all children <2 years of age who were admitted to Turku University Hospital because of bronchiolitis in the months of August-December during 1988-2001. The primary outcome was recurrent wheezing that required long-term asthma medication. Data on asthma medications of the individual children were derived from the Social Insurance Institution of Finland. RESULTS: Within the first year after hospitalization, 36 of 217 (16.6%) children with non-RSV bronchiolitis developed recurrent wheezing, compared with five of 199 (2.5%) children with RSV bronchiolitis [relative risk (RR) 6.6; 95% confidence interval (CI) 2.6-16.5]. The rates of recurrent wheezing were significantly increased in the non-RSV group also within 2 years (RR 2.9; 95% CI 1.7-5.1) and 3 years (RR 3.4; 95% CI 2.0-5.7) after hospitalization. The increased risk of recurrent wheezing in children with non-RSV-associated bronchiolitis was observed both in boys and girls at all time points of the 3-year follow-up, and it was not explained by the age difference between the RSV and non-RSV groups or any confounding seasonal factors. CONCLUSION: Children hospitalized with bronchiolitis caused by other viruses than RSV develop recurrent wheezing at substantially higher rates during a 3-year follow-up period than do children with RSV-induced bronchiolitis.
机译：背景：最近的研究表明，与呼吸道合胞病毒（RSV）相关的早期喘息相比，与鼻病毒相关的早期喘息是儿童反复发作喘息的更大危险因素。我们确定了因RSV或非RSV细支气管炎住院后3年内小儿反复喘息的发生情况。方法：我们回顾性分析了1988-2001年8月至12月间所有由于毛细支气管炎而入住图尔库大学医院的2岁以下儿童。主要结局是反复喘息，需要长期哮喘药物治疗。有关个别儿童的哮喘药物的数据来自芬兰社会保险协会。结果：住院后第一年内，217例非RSV细支气管炎患儿中有36例复发性喘息，而199例（2.5％）的RSV细支气管炎患儿中有5例发生喘息[相对风险（RR）6.6; 95％置信区间（CI）2.6-16.5]。在非RSV组中，住院后2年内（RR 2.9; 95％CI 1.7-5.1）和3年内（RR 3.4; 95％CI 2.0-5.7）反复喘息的发生率也显着增加。在3年随访的所有时间点，男孩和女孩均观察到非RSV相关性毛细支气管炎患儿反复喘息的风险增加，但RSV与非RSV患儿之间的年龄差异无法解释RSV群体或任何令人困惑的季节性因素。结论：由RSV以外的其他病毒引起的毛细支气管炎住院儿童在3年的随访期间比RSV引起的毛细支气管炎患儿复发性喘息的发生率高得多。

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