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首页> 外文期刊>Allergy >Does the pill make a difference? Previous maternal use of contraceptive pills and allergic diseases among offspring.
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Does the pill make a difference? Previous maternal use of contraceptive pills and allergic diseases among offspring.

机译：药丸会有所作为吗？先前母亲在后代中使用避孕药和过敏性疾病。

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BACKGROUND: Maternal use of oral contraceptive pills (OCPs) might increase the prevalence of allergic diseases among offspring. The aim of the study was to clarify if there are differences between OCP types in this association. METHODS: Primary outcomes were asthma, allergic rhinitis and atopic eczema among 1182 children (618 asthmatic and 564 controls) aged 5-6 years. RESULTS: Maternal previous use of desogestrel, gestodene or cyproterone acetate before pregnancy, each combined with ethinyloestradiol (EO), increased the risk of allergic rhinitis among offspring compared with those children whose mothers had not used OCPs (OR 1.67, 95% CI 1.07-2.59, P < 0.024), and this risk was increased mainly in those children with parental allergy (OR 1.78, 95% CI 1.11-2.86, P < 0.018), especially in boys (OR 2.12, 95% CI 1.17-3.84, P < 0.014). No associations were observed between maternal use of OCPs before pregnancy and asthma or atopic eczema among offspring. The association between the previous use of OCPs andallergic rhinitis was not mediated through maternal sex steroid levels during early pregnancy, but women who had used more androgenic types of progestin formulas had higher serum levels of progesterone during early pregnancy. CONCLUSION: Maternal previous use of desogestrel, gestodene or cyproterone acetate before pregnancy, each combined with EO, increased the risk of allergic rhinitis among offspring compared with those children whose mothers had not used OCPs and this risk was detected mainly in boys and in children with parental allergy.
机译：背景：孕妇口服避孕药（OCPs）可能会增加后代中过敏性疾病的患病率。该研究的目的是弄清楚在这种关联中OCP类型之间是否存在差异。方法：主要结果是哮喘，过敏性鼻炎和特应性湿疹在1182名5-6岁的儿童（618名哮喘和564名对照组）中。结果：与母亲未使用过OCP的儿童相比，母亲先前在怀孕前使用去氧孕烯，孕二烯酮或醋酸环丙孕酮，再与乙炔雌二醇（EO）结合使用，增加了后代发生过敏性鼻炎的风险（OR 1.67，95％CI 1.07- 2.59，P <0.024），并且这种风险主要在父母过敏的儿童中增加（OR 1.78，95％CI 1.11-2.86，P <0.018），尤其是男孩（OR 2.12，95％CI 1.17-3.84，P <0.014）。孕妇在怀孕前使用OCP与后代哮喘或特应性湿疹之间没有关联。早期使用OCP与变应性鼻炎之间的关联并没有通过孕早期母体性类固醇水平的调节来介导，但是使用更多雄激素类型的孕激素配方的女性在孕早期血清中的孕酮水平较高。结论：与母亲未使用过OCP的儿童相比，母亲先前在怀孕前曾使用过地索孕酮，孕二烯酮或醋酸环丙孕酮与EO联合使用会增加后代发生过敏性鼻炎的风险，这种风险主要在男孩和患有OCP的儿童中发现父母过敏。

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