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首页> 外文期刊>Allergy >The role of parasitic infections in atopic diseases in rural schoolchildren.
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The role of parasitic infections in atopic diseases in rural schoolchildren.

机译：农村学龄儿童寄生虫感染在特应性疾病中的作用。

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BACKGROUND: There is increasing evidence that the farming environment has a protective effect as regards allergic diseases. Exposure to animal parasites, particularly helminth infections, is common in the farming environment. However, the role of helminths in this environment is not well determined to date. METHODS: This analysis focuses on 613 children 6-13 years of age from rural areas of Austria, Germany and Switzerland, who took part in the Allergy and Endotoxin (ALEX) study. Allergic diseases and farming characteristics were assessed by a standardized questionnaire and as a crude measure of possible exposure to helminths, IgG antibodies to Ascaris lumbricoides were measured. RESULTS: Exposure to nematodes, as determined by the levels of antibody to A. lumbricoides, was more frequent among farmers' children than non-farmers' children (39.8%vs 31.1%, P = 0.03). This positive serology was found to be significantly associated with high total IgE levels [odds ratio (OR) = 3.05, 95% confidence interval (CI) = 1.81-5.12] and eosinophilia (OR = 2.84, 95% CI = 1.66-4.84). However, no association between anti-nematode serology and the prevalences of asthma, wheeze, hay fever or atopy was found. A weak association for atopy was observed after adjustment for total IgE. CONCLUSION: Immunoglobulin G antibodies to A. lumbricoides, as a crude measure of possible exposure to helminths, did not indicate any protective effect against allergic diseases in this population. Although farmers' children had increased antibody levels reactive to helminth parasites indicating exposure, this did not explain the protective effect of farming against atopic diseases.
机译：背景：越来越多的证据表明，耕作环境对过敏性疾病具有保护作用。在农业环境中，动物寄生虫尤其是蠕虫感染是很常见的。但是，到目前为止，蠕虫在这种环境中的作用尚不十分确定。方法：本分析的重点是来自奥地利，德国和瑞士农村地区的613位6-13岁的儿童，他们参与了变态反应和内毒素（ALEX）研究。通过标准化问卷调查评估过敏性疾病和农业特性，并作为可能暴露于蠕虫的粗略度量，测量了A虫的IgG抗体。结果：由线虫的抗体水平决定的线虫接触在农民子女中比非农民子女更为频繁（39.8％vs 31.1％，P = 0.03）。发现这种阳性血清学与高总IgE水平显着相关[比值比（OR）= 3.05，95％置信区间（CI）= 1.81-5.12]和嗜酸性粒细胞增多症（OR = 2.84，95％CI = 1.66-4.84） 。但是，未发现抗线虫血清学与哮喘，喘息，花粉症或特应性感染的患病率之间存在关联。调整总IgE后，观察到特应性的弱关联。结论：针对粗线虫的免疫球蛋白G抗体，作为可能暴露于蠕虫的粗略度量，并未表明该人群对变应性疾病有任何保护作用。尽管农民的孩子对蠕虫寄生虫具有反应性的抗体水平升高，表明有接触，但这不能解释农业对特应性疾病的保护作用。

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