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首页> 外文期刊>Allergy >IgE antibodies to betalactams: relationship between the triggering hapten and the specificity of the immune response.
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IgE antibodies to betalactams: relationship between the triggering hapten and the specificity of the immune response.

机译：抗内酰胺的IgE抗体：触发的半抗原与免疫反应特异性之间的关系。

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BACKGROUND: In immunoglobulin (Ig)E-mediated responses to betalactams (BL) the antibody is directed to the hapten inducing the response. For benzylpenicillin (BP) the determinant is benzylpenicilloyl (BPO) and for amoxicillin (AX), amoxicilloyl (AXO). Because of cross-reactivity, IgE from some patients reacts to both drugs whereas others have a drug-selective recognition. After an allergic episode, there is an increase in IgE that decreases over time. We analysed the response of patients allergic to BL after penicillin administration, with emphasis on IgE cross-reactivity. METHODS: Subjects who developed an IgE antibody response were studied. Sequential follow-up samples were obtained at different times during the response. Changes in IgE specificity were analysed by competition immunoassays using different penicillin monomeric conjugates. RESULTS: Two patterns of response were existed: one with IgE directed to the culprit penicillin and another with IgE mainly reactive to BPO. In both, a variable cross-reactivity with the hapten triggering the boosting response was found. This pattern was maintained with no change in specificity over time, even in subjects who experienced one boosting event. CONCLUSION: The IgE response can be specific to the drug inducing the reaction or cross-reactive to the classical BPO determinant. This pattern is maintained throughout the whole period of the response, even if re-exposure occurs. The stability of the type of response can be explained by the phenomenon of original antigenic sin: in the presence of antibodies, memory B cells are more easily triggered than naive B cells.
机译：背景：在免疫球蛋白（Ig）E介导的对内酰胺（BL）的应答中，抗体针对的是半抗原诱导的应答。对于苄青霉素（BP），决定因素是苄青霉素（BPO），对于阿莫西林（AX），阿莫西林（AXO）是决定因素。由于交叉反应，一些患者的IgE对两种药物都有反应，而其他患者则具有药物选择性识别。变态反应发作后，IgE会随着时间的推移而增加。我们分析了青霉素给药后对BL过敏的患者的反应，重点是IgE交叉反应性。方法：研究产生IgE抗体应答的受试者。在反应期间的不同时间获得了顺序的随访样本。通过使用不同的青霉素单体结合物的竞争性免疫分析来分析IgE特异性的变化。结果：存在两种反应模式：一种是针对罪魁祸首青霉素的IgE，另一种是主要对BPO有反应性的IgE。在这两种方法中，均发现了与半抗原触发增强反应的可变交叉反应性。即使在经历了一次加强事件的受试者中，这种模式也不会随时间变化而保持特异性。结论：IgE反应可能是特定于药物诱导的反应或与经典的BPO决定簇发生交叉反应。即使发生再次暴露，这种模式也会在整个响应期间保持不变。反应类型的稳定性可以通过原始抗原罪的现象来解释：在存在抗体的情况下，记忆B细胞比原始B细胞更容易被触发。

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