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首页> 外文期刊>Allergy >Gene-vitamin D interactions on food sensitization: a prospective birth cohort study.
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Gene-vitamin D interactions on food sensitization: a prospective birth cohort study.

机译：基因-维生素D对食物致敏的相互作用：前瞻性出生队列研究。

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BACKGROUND: It has been hypothesized that vitamin D deficiency (VDD) contributes to the development of food sensitization (FS) and then food allergy. However, the epidemiological evidence is conflicting. We aim to examine whether cord blood VDD is associated with FS and whether such association can be modified by genetic variants in a prospective birth cohort. METHODS: This study included 649 children who were enrolled at birth and followed from birth onward at the Boston Medical Center. We defined VDD as cord blood 25(OH)D < 11 ng/ml, and FS as specific IgE >/= 0.35 kUA/l to any of eight common food allergens in early childhood. We genotyped potentially functional single-nucleotide polymorphisms (SNPs) in 11 genes known to be involved in regulating IgE and 25(OH)D concentrations. Logistic regressions were used to test the effects of VDD on FS individually and jointly with SNPs. RESULTS: Among the 649 children, 44% had VDD and 37% had FS. When examined alone, VDD was not associated with FS. When examined jointly with SNPs, a significant interaction between IL4 gene polymorphism (rs2243250) and VDD (p(interaction) = 0.003, p(FDR) = 0.10) was found: VDD increased the risk of FS among children carrying CC/CT genotypes (OR = 1.79, 95%CI: 1.15-2.77). Similar but weaker interactions were observed for SNPs in MS4A2 (rs512555), FCER1G (rs2070901), and CYP24A1 (rs2762934). When all four SNPs were simultaneously considered, a strong gene-VDD interaction was evident (p(interaction) = 9 x 10(-6) ). CONCLUSIONS: Our data demonstrate that VDD may increase the risk of FS among individuals with certain genotypes, providing evidence of gene-vitamin D interaction on FS.
机译：背景：据推测，维生素D缺乏症（VDD）有助于食物致敏（FS）的发展，进而导致食物过敏。但是，流行病学证据相互矛盾。我们旨在检查脐带血VDD是否与FS相关，以及是否可以通过前瞻性出生队列中的遗传变异来改变这种关联。方法：该研究纳入了649例出生时出生的儿童，并从出生开始一直在波士顿医学中心接受随访。我们将VDD定义为脐带血25（OH）D <11 ng / ml，而FS定义为儿童早期八种常见食物过敏原中任何一种的特异性IgE> / = 0.35 kUA / l。我们对11个已知参与调节IgE和25（OH）D浓度的基因进行了潜在功能性单核苷酸多态性（SNP）的基因分型。逻辑回归用于单独和与SNP一起测试VDD对FS的影响。结果：在649名儿童中，有44％的儿童患有VDD，37％的儿童患有FS。单独检查时，VDD与FS无关。与SNP一起检查时，发现IL4基因多态性（rs2243250）与VDD之间存在显着的相互作用（p（相互作用）= 0.003，p（FDR）= 0.10）：VDD增加了携带CC / CT基因型儿童的FS风险（ OR = 1.79，95％CI：1.15-2.77）。对于MS4A2（rs512555），FCER1G（rs2070901）和CYP24A1（rs2762934）中的SNP，观察到相似但较弱的相互作用。当同时考虑所有四个SNP时，很明显的基因-VDD相互作用很明显（p（interaction）= 9 x 10（-6））。结论：我们的数据表明，VDD可能会增加某些基因型个体的FS风险，为FS基因维生素D相互作用提供了证据。

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