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Association of allergic patients' phenotypes with IgE reactivity to recombinant pollen marker allergens

机译：过敏患者的表型与IgE反应与重组花粉标记过敏原的关系

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Background: During the last decade allergen molecules from several allergen sources have been produced by recombinant DNA technology. The aim of this study was to investigate whether IgE reactivity to recombinant pollen allergens with broad and narrow cross-reactivity is associated with clinical phenotypes of allergic sensitiza-tion.Methods: Serum IgE reactivity to a panel of six recombinant birch and grass pollen allergens was measured by ELISA in pollen sensitized patients from Central Europe to define groups of patients with exclusive IgE reactivity to rBet v 1, with exclusive reactivity to major grass pollen allergens (rPhl p 1, rPhl p 2, rPhl p 5) and with IgE reactivity to cross-reactive pollen allergens (rBet v 2, rPhl p 7). Patients' clinical phenotypes were recorded. IgE responses to tree, grass and weed pollen as well as plant food extracts were evaluated in vitro by CAP-FEIA and clinical sensitivities were confirmed in vivo by skin prick testing.Results: IgE reactivity to the recombinant major birch pollen allergen, rBet v 1, was associated with sensitization to pollen from birch, taxonomically related trees and to certain plant-derived food. Reactivity to the recombinant timothy grass pollen allergens, rPhl p 1, rPhl p 2, rPhl p 5, indicated sensitization to pollen from grasses. Patients reacting with the highly cross-reactive allergen rPhl p 7 were polysensitized to pollen from unrelated trees, grasses and weeds and rBet v 2-positive patients were polysensitized to pollen and plant-derived food from unrelated plants.Conclusions: IgE reactivity to recombinant marker allergens is associated with clinical phenotypes of allergic sensitization and may be useful for the selection of treatment strategies.
机译：背景：在过去的十年中，通过重组DNA技术生产了来自多种过敏原的过敏原分子。这项研究的目的是调查对具有广泛和狭窄交叉反应性的重组花粉变应原的IgE反应性是否与变态反应致敏的临床表型相关。方法：对一组六种重组桦树和草花粉变应原的血清IgE反应性通过ELISA对来自中欧的花粉致敏患者进行了测定，确定了对rBet v 1具有唯一IgE反应性，对主要草花粉变应原具有唯一反应性（rPhl p 1，rPhl p 2，rPhl p 5）和对IgE交叉反应的花粉过敏原（rBet v 2，rPhl p 7）。记录患者的临床表型。通过CAP-FEIA体外评估了IgE对树木，草和杂草花粉以及植物食品提取物的反应，并通过皮肤点刺试验确定了体内的临床敏感性。结果：IgE对重组主要桦树花粉变应原rBet v 1的反应性与花粉对桦树，与分类学相关的树木的花粉以及某些植物衍生的食物的敏感性有关。对重组提摩西草花粉变应原的反应性，rPhl p 1，rPhl p 2，rPhl p 5，表明对草的花粉敏感。对高度交叉反应的过敏原rPhl p 7有反应的患者对不相关的树木，草和杂草的花粉具有多重敏感性，对rBet v 2阳性的患者对不相关的植物的花粉和植物来源的食品具有多重敏感性。结论：IgE对重组标记具有反应性变应原与变态反应致敏的临床表型有关，可能有助于选择治疗策略。

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