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首页> 外文期刊>Allergy >Time trends in the prevalence of peanut allergy: three cohorts of children from the same geographical location in the UK.
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Time trends in the prevalence of peanut allergy: three cohorts of children from the same geographical location in the UK.

机译：花生过敏流行的时间趋势：来自英国同一地理位置的三组儿童。

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BACKGROUND: This article investigated the prevalence of peanut allergy in three cohorts of children born in the same geographical location, Isle of Wight, UK and seeks to determine whether the prevalence of peanut allergy has changed between 1994 and 2004. METHODS: Three cohorts of children (age 3-4 years) born on the Isle of Wight, were assessed for peanut allergy and the outcomes compared: Cohort A: Born in 1989; reviewed at 4 years of age (n = 2181). Cohort B: Born between 1994 and 1996; reviewed between 3 and 4 years of age (n = 1273). Cohort C: Born between 2001 and 2002; reviewed at 3 years of age (n = 891). RESULTS: Peanut sensitization increased significantly from 1.3% in Cohort A to 3.3% (P = 0.003) in Cohort B before falling back to 2.0% in Cohort C (P = 0.145). Similarly, clinical peanut allergy increased significantly from 0.5% in Cohort A to 1.4% (P = 0.023) in Cohort B, with a subsequent fall to 1.2% in Cohort C (P = 0.850). CONCLUSIONS: Our data from three cohorts of 3- to 4-year-old children born in the same geographical area shows that peanut allergy prevalence has changed over time. Peanut sensitization and reported allergy in children born in 1994-1996 increased from 1989 but seems to have stabilized or slightly decreased since the late 1990s, although not significant.
机译：背景：本文调查了在英国怀特岛同一地理位置出生的三个队列儿童的花生过敏症患病率，旨在确定1994年至2004年之间花生过敏症的患病率是否发生了变化。方法：三个队列儿童对怀特岛出生的（3-4岁）花生过敏症进行了评估，并对结局进行了比较：队列A：出生于1989;在4岁时复查（n = 2181）。组别B：生于1994年至1996年;回顾了3至4岁的年龄（n = 1273）。组别C：生于2001年至2002年之间;在3岁时复查（n = 891）。结果：花生致敏性从队列A的1.3％显着增加到队列B的3.3％（P = 0.003），然后又下降到队列C的2.0％（P = 0.145）。同样，临床花生过敏从队列A的0.5％显着增加到队列B的1.4％（P = 0.023），随后下降到队列C的1.2％（P = 0.850）。结论：我们在同一地理区域出生的3个3至4岁儿童队列的数据表明，花生过敏症患病率随时间变化。 1994年至1994年出生的儿童对花生的致敏作用和报告的变态反应自1989年以来有所增加，但自1990年代后期以来似乎稳定或略有下降，尽管不明显。

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