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Health-related quality of life of food allergic patients measured with generic and disease-specific questionnaires.

机译：用一般和针对特定疾病的调查表测量的食物过敏患者的健康相关生活质量。

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BACKGROUND: Health-related quality of life (HRQL) has never been measured with both generic and disease-specific questionnaires in the same group of food allergic patients. The aim of this study was to compare HRQL of food allergic patients as measured with generic and disease-specific questionnaires. METHODS: Generic questionnaires (CHQ-CF87 and RAND-36) and disease-specific HRQL questionnaires (FAQLQ-CF, -TF and -AF) were completed by 79 children, 74 adolescents and 72 adults with food allergy. Floor and ceiling effects, percentage of agreement and multivariate stepwise regression analysis were used to compare the generic and disease-specific measurements. RESULTS: The Food Allergy Quality of Life Questionnaires (FAQLQs) showed minimal floor or ceiling effects. The CHQ-CF87 and RAND-36 showed minimal floor effects, but remarkable ceiling effects (> 73%) were found for the scales role functioning-emotional (RE), role functioning-behaviour (RB), role functioning-physical (RP) in children and adolescents and the scale RE (> 79%) in adults. Additionally, we found low percentages of agreement between the generic and disease-specific questionnaires to identify the same food allergic patients with the best or worst HRQL. Only patients with the best disease-specific HRQL also tended to have the best generic HRQL. Finally, the explained variance in HRQL by patient characteristics was higher in the disease-specific questionnaires (30.7-62.8%) than in the generic scales (6.7-31.7%). CONCLUSION: Disease-specific HRQL questionnaires may be more suitable to measure clinically important impairments in HRQL or HRQL differences over time in food allergic patients. However, generic HRQL questionnaires are indispensable for the comparison between different diseases and are thus complementary.
机译：背景：从未在同一组食物过敏患者中使用通用问卷和针对疾病的问卷来测量与健康相关的生活质量（HRQL）。这项研究的目的是比较食物过敏患者的HRQL，以一般和针对疾病的问卷进行测量。方法：由79名儿童，74名青少年和72名患有食物过敏的儿童填写了通用问卷（CHQ-CF87和RAND-36）和针对疾病的HRQL问卷（FAQLQ-CF，-TF和-AF）。地板和天花板的影响，一致性的百分比和多元逐步回归分析被用来比较一般的和特定疾病的测量。结果：《食物过敏生活质量问卷》（FAQLQs）对地板或天花板的影响最小。 CHQ-CF87和RAND-36表现出最小的地板效应，但在角色功能-情绪（RE），角色功能-行为（RB），角色功能-身体（RP）的量表中发现了显着的天花板效应（> 73％）。在儿童和青少年中的比例为RE（> 79％）。此外，我们发现通用问卷和针对特定疾病的问卷之间的百分比较低，可以识别出具有最佳或最差HRQL的相同食物过敏患者。只有具有最佳疾病特异性HRQL的患者也往往具有最佳的通用HRQL。最后，在特定疾病调查表中，由患者特征引起的HRQL差异较大（30.7-62.8％），比一般量表（6.7-31.7％）高。结论：针对疾病的HRQL问卷可能更适合于测量食物过敏患者随时间变化的HRQL或HRQL差异的重要临床意义。但是，通用的HRQL问卷对于不同疾病之间的比较是必不可少的，因此是互补的。

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