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Mucosal dendritic cells in allergy and immunotherapy.

机译:黏膜树突细胞的变态反应和免疫治疗。

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To cite this article: Novak N, Allam J-P. Mucosal dendritic cells in allergy and immunotherapy. Allergy 2011; 66 (Suppl. 95): 22-24. ABSTRACT: The oral epithelium contains oral mucosal Langerhans cells (oLCs) that constitutively express the high-affinity IgE-receptor FcepsilonRI, the lipopolysaccharide receptor CD14 and toll-like receptor (TLR)4. The distribution of oLCs profoundly differs at distinct oral mucosal sites, with higher numbers of oLCs detectable in the vestibulum compared with the sublingual region. The oLC response to activation of TLR4 and FcepsilonRI and to binding of allergen suggests that these cells are involved in the maintenance of tolerance towards bacterial components and allergens. Thus, oLCs are important targets for allergens and adjuvants during sublingual immunotherapy, and characterizing them is crucial for improving allergen-specific immunotherapy.
机译:引用本文:Novak N,Allam J-P。黏膜树突细胞的变态反应和免疫治疗。过敏2011; 66(Suppl.95):22-24。摘要:口腔上皮细胞含有组成型表达高亲和力IgE受体FcepsilonRI,脂多糖受体CD14和Toll样受体(TLR)4的口腔黏膜朗格汉斯细胞(oLC)。 oLC的分布在不同的口腔粘膜部位差异很大,与舌下区相比,前庭中可检测到的oLC数量更高。 OLC对TLR4和FcepsilonRI的激活以及对过敏原的结合的应答表明,这些细胞参与了对细菌成分和过敏原的耐受性维持。因此,oLC是舌下免疫治疗期间过敏原和佐剂的重要靶标,对其特性进行表征对于改善过敏原特异性免疫疗法至关重要。

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