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首页> 外文期刊>Allergy >Distinct eosinophil cytokine expression patterns in skin diseases - the possible existence of functionally different eosinophil subpopulations.
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Distinct eosinophil cytokine expression patterns in skin diseases - the possible existence of functionally different eosinophil subpopulations.

机译：皮肤疾病中不同的嗜酸性粒细胞细胞因子表达模式-功能上不同的嗜酸性粒细胞亚群的可能存在。

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BACKGROUND: The function of eosinophils has been attributed to host defense, immunomodulation, and fibrosis. Although eosinophils are found among infiltrating cells in a broad spectrum of skin diseases, their pathogenic role remains uncertain. This study aimed to analyze the cytokine expression by eosinophils in different skin diseases. METHODS: Skin specimens from different skin diseases [allergic/reactive, infectious, autoimmune, and tumors/lymphomas (LY)] were stained by antibodies directed to eosinophil cationic protein, cytokines [tumor necrosis factor (TNF)-alpha, interleukin (IL)-5, IL-6, IL-10, IL-11, IL-13, IL-17, IL-25, IL-33, interferon-gamma, transforming growth factor (TGF)-beta, and thymic stromal lymphopoietin], eotaxins (CCL11, CCL24, and CCL26), metalloproteinase (MMP)-9 as well as extracellular matrix proteins (tenascin-C and procollagen-3) and then analyzed by laser scanning microscopy. RESULTS: The number of eosinophils varied considerably in and between disease groups and did not correlate with the numbers of accompanying inflammatory cells. The expression of IL-5, IL-6, IL-11, TGF-beta, CCL24, and MMP-9 by eosinophils significantly differed between disease groups. Eosinophils in tumors/LY predominantly expressed IL-6, TGF-beta, and CCL24, but not IL-11. On the other hand, in autoimmune diseases, eosinophils largely contributed to MMP-9 production. IL-5-generating eosinophils were particularly obvious in allergic and infectious diseases. CONCLUSION: In skin diseases, eosinophil expresses a broad spectrum of cytokines. The different cytokine expression patterns suggest distinct functional roles of eosinophils in these diseases that might be related to host defense, immunomodulation, fibrosis, and/or tumor development.
机译：背景：嗜酸性粒细胞的功能已被归因于宿主防御，免疫调节和纤维化。尽管嗜酸性粒细胞在广泛的皮肤疾病中被发现在浸润细胞中，但是其致病作用仍然不确定。这项研究旨在分析嗜酸性粒细胞在不同皮肤疾病中的细胞因子表达。方法：用针对嗜酸性粒细胞阳离子蛋白，细胞因子[肿瘤坏死因子（TNF）-α，白介素（IL）]的抗体对不同皮肤疾病[过敏/反应性，感染性，自身免疫性和肿瘤/淋巴瘤（LY）]的皮肤样本进行染色。 -5，IL-6，IL-10，IL-11，IL-13，IL-17，IL-25，IL-33，γ-干扰素，转化生长因子（TGF）-β和胸腺基质淋巴细胞生成素]， eotaxins（CCL11，CCL24和CCL26），金属蛋白酶（MMP）-9以及细胞外基质蛋白（肌腱蛋白C和前胶原3），然后通过激光扫描显微镜进行分析。结果：嗜酸性粒细胞的数量在疾病组内和疾病组之间差异很大，并且与伴随的炎性细胞数量无关。嗜酸性粒细胞的IL-5，IL-6，IL-11，TGF-β，CCL24和MMP-9的表达在疾病组之间存在显着差异。肿瘤/ LY中的嗜酸性粒细胞主要表达IL-6，TGF-β和CCL24，但不表达IL-11。另一方面，在自身免疫性疾病中，嗜酸性粒细胞在很大程度上促进了MMP-9的产生。产生IL-5的嗜酸性粒细胞在变态反应和传染病中尤为明显。结论：在皮肤疾病中，嗜酸性粒细胞表达广泛的细胞因子。不同的细胞因子表达模式表明，嗜酸性粒细胞在这些疾病中的独特功能可能与宿主防御，免疫调节，纤维化和/或肿瘤发展有关。

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