2-Chloroacetamidine, a novel immunomodulator, suppresses antigen-induced mouse airway inflammation

Maezawa Y.; Paltser G.; Tsui H.; Cheung R.; Wu P.; Nicholas A. P.; Dosch H. -M.

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2-Chloroacetamidine, a novel immunomodulator, suppresses antigen-induced mouse airway inflammation

机译：2-氯乙acet，一种新型的免疫调节剂，抑制抗原诱导的小鼠气道炎症

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BackgroundCitrullination is a presently under-recognized posttranslational protein modification catalyzed by PAD enzymes. Immune responses to citrullinated neo-epitopes are identified in a growing number of inflammatory and autoimmune diseases. However, the involvement of hypercitrullination in the pathogenesis of bronchial asthma is still unknown.

机译：背景技术谷氨酰胺化是目前由PAD酶催化的，尚未被广泛认可的翻译后蛋白质修饰。在越来越多的炎性和自身免疫性疾病中鉴定出对瓜氨酸化的新表位的免疫反应。但是，尚不清楚超瓜氨酸参与支气管哮喘的发病机理。

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《Allergy》 |2015年第9期|共9页
作者
Maezawa Y.; Paltser G.; Tsui H.; Cheung R.; Wu P.; Nicholas A. P.; Dosch H. -M.;
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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
animal model; asthma; protein citrullination; T cell;

机译：动物模型;哮喘;蛋白质瓜氨酸化;T细胞;

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1. 2-Chloroacetamidine, a novel immunomodulator, suppresses antigen-induced mouse airway inflammation [J] . Maezawa Y., Paltser G., Tsui H., Allergy . 2015,第9期

机译：2-氯乙acet，一种新型的免疫调节剂，抑制抗原诱导的小鼠气道炎症
2. High Expression of IL-22 Suppresses Antigen-Induced Immune Responses and Eosinophilic Airway Inflammation via an IL-10-Associated Mechanism. [J] . Nakagome K, Imamura M, Kawahata K, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2011,第10期

机译：IL-22的高表达抑制通过IL-10相关机制的抗原诱导的免疫反应和嗜酸性气道炎症。
3. Subcutaneous immunotherapy suppresses Th2 inflammation and induces neutralizing antibodies, but sublingual immunotherapy suppresses airway hyperresponsiveness in grass pollen mouse models for allergic asthma [J] . Hesse L., Brouwer U., Petersen A. H., Clinical and experimental allergy : . 2018,第8期

机译：皮下免疫疗法抑制Th2炎症并诱导中和抗体，但舌下免疫疗法抑制了草花粉小鼠模型的气道高反应性，用于过敏性哮喘
4. Enhancement of Antigen-Induced Eosinophilic Inflammation in the Airways of Mice by Urban Particles in Beijing [C] . Miao He, Takamichi Ichinose, Seiichi Yoshida, Conference on Environmental Pollution and Public Health . 2012

机译：北京城市颗粒增强抗原诱导的小鼠气道嗜酸性粒细胞炎症
5. The Role and Effects of CD200R Activation in Murine Models of Allergic Airways Inflammation [D] . Woo, Lindsay N. 2019

机译：CD200R活化在过敏气道炎症鼠模型中的作用及影响
6. Disruption of antigen-induced airway inflammation and airway hyper-responsiveness in low affinity neurotrophin receptor p75 gene deficient mice [O] . Shota Tokuoka, Yoshimasa Takahashi, Taisei Masuda, 2001

机译：低亲和力神经营养蛋白受体p75基因缺陷小鼠中抗原诱导的气道炎症和气道高反应性的破坏
7. In Vivo IL-10 Gene Delivery Suppresses Airway Eosinophilia and Hyperreactivity by Down-Regulating APC Functions and Migration without Impairing the Antigen-Specific Systemic Immune Response in a Mouse Model of Allergic Airway Inflammation [O] . Kazuyuki Nakagome, Makoto Dohi, Katsuhide Okunishi, 2005

机译：体内IL-10基因递送抑制了气道嗜酸性粒细胞，通过降低APC功能和迁移，在过敏气道炎症的小鼠模型中迁移而不损害抗原特异性全身免疫应答的过度反应性

2-Chloroacetamidine, a novel immunomodulator, suppresses antigen-induced mouse airway inflammation

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