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首页> 外文期刊>Allergy >Management of hypersensitivity reactions to anti-D immunoglobulin preparations
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Management of hypersensitivity reactions to anti-D immunoglobulin preparations

机译：对抗D免疫球蛋白制剂的超敏反应的管理

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RhD immunoglobulin G (anti-D) administered to pregnant Rh(-) women prevents Rh isoimmunization. Its use has significantly reduced the incidence of haemolytic disease of the foetus and newborn previously responsible for one death in every 2200 births. In pregnancy, acute drug-induced hypersensitivity reactions including anaphylaxis can have serious deleterious effects on the mother and foetuseonate. Women can be erroneously labelled as drug allergic as the investigation of hypersensitivity reactions in pregnancy is complex and drug challenges are usually contraindicated. We present three cases of suspected anti-D hypersensitivity clinically presenting as anaphylaxis and delayed transfusion-related reaction. We also propose a new algorithm for the investigations of such reaction. It relies on detailed history, cautious interpretation of skin tests, foetal Rh genotyping from maternal blood and, in some cases, anti-D challenges. This is not to deprive women of anti-D which might put their future pregnancies at risk.
机译：孕妇Rh（-）妇女服用RhD免疫球蛋白G（抗D）可防止Rh同种免疫。它的使用显着降低了胎儿和新生儿溶血性疾病的发生率，以前这种溶血性疾病每2200例新生儿中就有1人死亡。在怀孕期间，包括过敏反应在内的急性药物诱发的超敏反应可能会对母亲和胎儿/新生儿产生严重的有害影响。妇女可能会被错误地标记为药物过敏，因为对孕妇的超敏反应的调查非常复杂，通常禁忌使用药物。我们介绍了三例疑似抗D超敏反应的临床表现，表现为过敏反应和延迟输血相关反应。我们还提出了一种研究这种反应的新算法。它依赖于详细的病史，对皮肤检查的谨慎解释，母体血液中的胎儿Rh Rh基因分型以及在某些情况下的抗D挑战。这并不是要剥夺妇女抗D的能力，因为这可能会使她们未来的怀孕处于危险之中。

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