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首页> 外文期刊>Allergy >Effect of grass pollen immunotherapy with Alutard SQ on quality of life in seasonal allergic rhinoconjunctivitis.
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Effect of grass pollen immunotherapy with Alutard SQ on quality of life in seasonal allergic rhinoconjunctivitis.

机译：Alutard SQ草花粉免疫疗法对季节性变应性鼻结膜炎患者生活质量的影响。

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BACKGROUND: Treatment of allergic rhinitis with subcutaneous allergen immunotherapy is effective in terms of reductions in symptoms and seasonal use of reliever medication. Its effect on quality of life (QoL), reflecting the impact of symptoms on work/school performance and leisure activities is, however, important and often overlooked. AIMS OF THE STUDY: To assess effect on QoL of specific immunotherapy with two doses of Alutard SQ Phleum pratense in patients with moderately to severe seasonal allergic rhinoconjunctivitis inadequately controlled by standard drug therapy. METHODS: Double-blind, randomized, placebo-controlled study of 410 patients with seasonal allergic rhinoconjunctivitis. Participants were randomized (2 : 1 : 1) to receive Alutard SQ P. pratense (ALK-Abello) at maintenance doses of 100,000 SQ-U (203 subjects), 10,000 SQ-U (104 subjects) or placebo (103 subjects) given by subcutaneous injections. The groups were well matched for demographics and baseline symptoms. Quality of life was assessed using the Rhinoconjunctivitis Quality of Life Questionnaire which covers seven domains of health before and in the peak of the pollen season. RESULTS: While all domain scores were significantly improved when comparing 100,000 SQ-U with placebo, two domain scores were significantly improved when comparing 10,000 SQ-U with placebo. When comparing 100,000 SQ-U with 10,000 SQ-U, four domain scores were significantly improved. CONCLUSION: Treatment with Alutard SQ significantly improved the seasonal QoL of patients suffering from allergic rhinoconjunctivitis. The improvement was more pronounced and wider ranging in patients who received the higher 100,000 SQ-U maintenance dose.
机译：背景：皮下变应原免疫疗法治疗变应性鼻炎在减轻症状和缓解药物的季节性使用方面是有效的。然而，它对生活质量（QoL）的影响很重要，并且经常被忽视，反映出症状对工作/学校表现和休闲活动的影响。研究目的：评估在标准药物治疗控制不力的中度至重度季节性变应性鼻结膜炎患者中，两剂Alutard SQ Phleum pratense对特定免疫疗法对QoL的影响。方法：对410例季节性变应性鼻结膜炎患者进行双盲，随机，安慰剂对照研究。参与者被随机（2：1：1）接受维持剂量为100,000 SQ-U（203位受试者），10,000 SQ-U（104位受试者）或安慰剂（103位受试者）的维持剂量的Alutard SQ Pratense（ALK-Abello）通过皮下注射。这些组在人口统计学和基线症状方面非常匹配。使用鼻结膜炎生活质量问卷评估生活质量，该问卷涵盖了花粉旺季之前和高峰期的七个健康领域。结果：将100,000 SQ-U与安慰剂进行比较时，所有领域得分均得到显着改善，而将10,000 SQ-U与安慰剂进行比较，则两个领域得分均得到明显改善。将100,000 SQ-U与10,000 SQ-U进行比较时，四个域得分得到了显着改善。结论：Alutard SQ治疗显着改善了过敏性鼻结膜炎患者的季节性QoL。在接受更高的100,000 SQ-U维持剂量的患者中，改善更为明显，范围更广。

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