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The protective effect of rural living against atopy in Mongolia.

机译：蒙古农村生活对特应性的保护作用。

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Background: Farm environment in childhood protects against atopy. We investigated in a population-based study in Mongolia the effects of rural living and migration from rural to urban areas on the risk of atopy. Methods: The screening study data of 9453 subjects, aged 10-60 years, were used for taking the sample for the clinical study in which 869 subjects were examined. Asthma, allergic rhinoconjunctivitis and sensitization were clinically defined and their risk factors analysed by logistic regression. Results: The risks of allergic rhinoconjunctivitis [adjusted odds ratio (OR) 0.43, 95% confidence interval (CI) 0.19-0.98] and allergic sensitization (OR 0.26, 95% CI 0.13-0.55) were the lowest in subjects living in a village from birth and intermediate in subjects who had relocated from a village to a town (OR for rhinoconjunctivitis 0.68, 95% CI 0.36-1.27, OR for sensitization 0.62, 95% CI 0.35-1.12) compared with subjects living in a town from birth. Simultaneous exposure to herd animals and dung heating decreased the risk of atopy. Keeping animals was a risk-factor for asthma only in Ulaanbaatar city. Conclusions: Continuing farm exposure after childhood may be important in reducing the risk of atopy.
机译：背景：童年时期的农场环境可以预防特应性疾病。我们在蒙古进行了一项基于人口的研究，调查了农村生活和从农村向城市迁移对特应性风险的影响。方法：使用9453名年龄在10-60岁的受试者的筛选研究数据作为临床研究样本，对869名受试者进行了检查。临床定义了哮喘，变应性鼻结膜炎和致敏性，并通过逻辑回归分析了其危险因素。结果：过敏性结膜炎的风险[校正比值比（OR）0.43，95％置信区间（CI）0.19-0.98]和过敏性致敏性（OR 0.26，95％CI 0.13-0.55）在乡村中最低。与出生时居住在城镇的受试者相比，从乡村搬到镇上的受试者的出生和中期（鼻结膜炎的OR为0.68，95％CI 0.36-1.27，致敏度为0.62，95％CI 0.35-1.12）。同时接触畜群动物和粪便加热降低了特应性风险。仅在乌兰巴托市，饲养动物才是哮喘的危险因素。结论：儿童期以后继续暴露于农场可能对降低特应性风险很重要。

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