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首页> 外文期刊>Allergy >Grass allergen tablet immunotherapy relieves individual seasonal eye and nasal symptoms, including nasal blockage.
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Grass allergen tablet immunotherapy relieves individual seasonal eye and nasal symptoms, including nasal blockage.

机译：草过敏原片免疫疗法可缓解个体的季节性眼和鼻症状，包括鼻塞。

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BACKGROUND: Symptoms of allergic rhinitis have a considerable impact on the quality of life of the sufferer. Sneezing, runny nose, blocked nose and headache are some of the most common symptoms of allergic rhinitis, which affects work, home and social life for many patients. Sublingual immunotherapy has shown to induce a protective immune response and provide sustained symptom prevention for allergic patients. AIMS OF THE TRIAL: The overall aims were to investigate the efficacy and safety of a sublingual grass allergen tablet (Grazax) 75 000 SQ-T; ALK-Abello A/S, Denmark). Reported here are the effects of Grazax on individual eye and nasal symptoms. METHODS: The trial was a double-blind placebo-controlled trial including 634 participants with significant rhinoconjunctivitis because of grass pollen. Participants were randomized 1 : 1 to Grazax (a fast dissolving, once daily immunotherapy tablet for home administration) or placebo and received treatment for at least 16 weeks prior to and continuing during the grass pollen season of 2005. Four nasal symptoms and two eye symptoms were scored on a scale from 0 (no symptoms) to 3 (severe symptoms) every day during the entire grass pollen season. Nasal symptoms included runny nose, blocked nose, sneezing and itchy nose; eye symptoms included gritty feeling/red/itchy eyes and watery eyes. RESULTS: Consistent and highly significant reductions in individual eye and nasal symptoms (from 22 to 44%) were observed following treatment with Grazax as compared with placebo (P < 0.0001). CONCLUSIONS: Grazax has effects on multiple allergic symptoms, including nasal blockage, and is an effective treatment of rhinoconjunctivitis, thereby reducing the need for topical anti-allergic drugs.
机译：背景：过敏性鼻炎的症状对患者的生活质量有很大影响。打喷嚏，流鼻涕，鼻子阻塞和头痛是过敏性鼻炎的一些最常见症状，会影响许多患者的工作，家庭和社交生活。舌下免疫疗法已显示可诱导保护性免疫反应，并为过敏性患者提供持续的症状预防。试验的目的：总体目标是研究舌下草过敏原片（Grazax）75 000 SQ-T的功效和安全性;丹麦ALK-Abello公司）。此处报告的是Grazax对个别眼睛和鼻部症状的影响。方法：该试验是一项双盲安慰剂对照试验，包括634名因花粉引起的严重鼻结膜炎的参与者。参与者按1：1的比例随机分配到Grazax（一种速溶型，每日一次用于家庭给药的免疫治疗片）或安慰剂，并在2005年草花粉季节开始之前并持续至少16周接受治疗。四种鼻部症状和两种眼部症状在整个花粉季节中，每天的评分从0（无症状）到3（严重症状）。鼻部症状包括流鼻涕，鼻子阻塞，打喷嚏和鼻子发痒;眼睛症状包括坚硬的感觉/红/痒的眼睛和水汪汪的眼睛。结果：与安慰剂相比，用Grazax治疗后观察到的个体眼和鼻部症状持续且高度显着减少（从22％降至44％）（P <0.0001）。结论：Grazax可对多种过敏症状（包括鼻塞）产生影响，并且是鼻结膜炎的有效治疗方法，从而减少了对局部抗过敏药物的需求。

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