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首页> 外文期刊>Allergy >Foxp3(+) regulatory T cells are expanded in severe atopic dermatitis patients
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Foxp3(+) regulatory T cells are expanded in severe atopic dermatitis patients

机译：Foxp3（+）调节性T细胞在严重的特应性皮炎患者中扩增

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Regulatory T cells (Tregs) are known to play critical roles in homeostasis and immune responses in the skin. Whether Treg frequencies are altered in atopic dermatitis (AD) patients has been addressed by several studies, leading to conflicting results. The detection of Tregs by FOXP3 expression may lead to false-positive results as activated T cells without regulatory function may transiently upregulate this transcription factor. In contrast, measurement of the DNA methylation status of a region within the FOXP3 locus that is selectively demethylated only in bona fide Tregs (Treg-specific demethylated region, TSDR) represents a reliable method to quantify Tregs. Here, we measured circulating Treg frequencies of adult patients and detected a positive correlation with disease severity. Subsequent surface marker analysis revealed higher frequencies of CD45RA(+) CCR7(-) tissue-homing Tregs in the patient group with a tendency of reduced expression of CD39 compared with healthy donors, a marker for the highly suppressive T-REM subtype.
机译：已知调节性T细胞（Tregs）在皮肤的体内稳态和免疫反应中起关键作用。几项研究已经探讨了特应性皮炎（AD）患者中Treg频率是否改变，导致了矛盾的结果。通过FOXP3表达检测Treg可能导致假阳性结果，因为没有调节功能的活化T细胞可能会暂时上调该转录因子。相反，仅在善意的Treg（Treg特异性脱甲基区域，TSDR）中选择性去甲基化的FOXP3基因座区域的DNA甲基化状态的测量代表了定量Treg的可靠方法。在这里，我们测量了成年患者的循环Treg频率，并发现与疾病严重程度呈正相关。随后的表面标志物分析显示，与健康的供体（高度抑制性T-REM亚型的标志物）相比，患者组中CD45RA（+）CCR7（-）组织归巢的Treg频率更高，且CD39表达降低。

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