MicroRNA-155 modulates P2R signaling and Th2 priming of dendritic cells during allergic airway inflammation in mice

Zech A.; Ayata C. K.; Pankratz F.; Meyer A.; Baudiss K.; Cicko S.; Yegutkin G. G.; Grundmann S.; Idzko M.

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MicroRNA-155 modulates P2R signaling and Th2 priming of dendritic cells during allergic airway inflammation in mice

机译：MicroRNA-155在小鼠过敏性气道炎症过程中调节树突状细胞的P2R信号传导和Th2启动

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BackgroundDendritic cells (DCs) are the professional antigen-presenting cells (APCs) in the lung. They are known to be key players in the induction and maintenance of allergic asthma by cross-linking innate and adaptive immune responses. MicroRNAs (miRNAs) are known to influence cell fate and function by translational suppression or induction of messenger RNA (mRNA) degradation. miR-155 has been shown to be a crucial regulator of the immune system. However, its function in the pathogenesis of allergic airway inflammation (AAI) is not completely elucidated yet.

机译：背景树突细胞（DC）是肺中的专业抗原呈递细胞（APC）。通过将先天性和适应性免疫反应交联，已知它们是诱导和维持过敏性哮喘的关键因素。已知MicroRNA（miRNA）通过翻译抑制或诱导Messenger RNA（mRNA）降解来影响细胞命运和功能。已证明miR-155是免疫系统的关键调节剂。然而，其在变应性气道炎症（AAI）发病机理中的功能尚未完全阐明。

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《Allergy》 |2015年第9期|共9页
作者
Zech A.; Ayata C. K.; Pankratz F.; Meyer A.; Baudiss K.; Cicko S.; Yegutkin G. G.; Grundmann S.; Idzko M.;
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正文语种 eng
中图分类医学免疫学;
关键词
allergic airway inflammation; dendritic cells; microRNA-155; P2R signaling; Th2 response;

机译：变应性气道炎症;树突状细胞;microRNA-155;P2R信号传导;Th2反应;

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1. MicroRNA-155 modulates P2R signaling and Th2 priming of dendritic cells during allergic airway inflammation in mice [J] . Zech A., Ayata C. K., Pankratz F., Allergy . 2015,第9期

机译：MicroRNA-155在小鼠过敏性气道炎症过程中调节树突状细胞的P2R信号传导和Th2启动
2. Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice (vol 2015, 678487, 2015) [J] . Lee Chen-Chen, Wang Ching-Chiung, Huang Huei-Mei, Evidence-based complementary and alternative medicine: eCAM . 2017,第6期

机译：通过调节树突细胞的功能并改善Th2介导的小鼠的过敏气道炎症（Vol 2015,678487，2015）来诱导Th1响应
3. Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice (vol 2015, 678487, 2015) [J] . Lee Chen-Chen, Wang Ching-Chiung, Huang Huei-Mei, Evidence-based complementary and alternative medicine: eCAM . 2017,第8期

机译：通过调节树突细胞的功能并改善Th2介导的小鼠的过敏气道炎症（Vol 2015,678487，2015）来诱导Th1响应
4. Mechanisms of Inhibition of Human Allergic Th2 Immune Responses by Regulatory T-Cells Induced by Interleukln 10-Treated Dendritic Cells and Transforming Growth Factor beta [C] . I. Bellinghausen, B. Konig, I. Bottcher, Collegium Internationale Allergologicum . 2007

机译：通过白细胞uck10-处理的树突细胞和转化生长因子β诱导的调节T细胞抑制人过敏Th2免疫应答的机制，转化生长因子β
5. TREM-2 and Dendritic Cells in the Pathogenesis of Allergic Airway Inflammation [D] . Hall, Sannette C. 2018

机译：过敏气道炎症发病机制中的TREM-2和树突细胞
6. Corrigendum to Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice [O] . Chen-Chen Lee, Ching-Chiung Wang, Huei-Mei Huang, 2017

机译：更正果糖酸通过调节树突状细胞的功能诱导Th1反应并改善小鼠Th2介导的过敏性气道炎症
7. Cytotoxic T lymphocyte antigen 4 immunoglobulin modified dendritic cells attenuate allergic airway inflammation and hyperresponsiveness by regulating the development of T helper type 1 (Th1)/Th2 and Th2/regulatory T cell subsets in a murine model of asthma [O] . Ying, L, Fu, Z, Luo, J, 2011

机译：细胞毒性T淋巴细胞抗原4免疫球蛋白修饰的树突状细胞通过调节哮喘小鼠模型中T辅助1型（Th1）/ Th2和Th2 /调节性T细胞亚群的发育来减轻过敏性气道炎症和反应过度

MicroRNA-155 modulates P2R signaling and Th2 priming of dendritic cells during allergic airway inflammation in mice

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