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首页> 外文期刊>Allergy >Associations of glutathione S-transferase P1, M1, and environmental tobacco smoke with wheezing illness in school children.
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Associations of glutathione S-transferase P1, M1, and environmental tobacco smoke with wheezing illness in school children.

机译：谷胱甘肽S-转移酶P1，M1和环境烟草烟雾与小学生喘息性疾病的关联。

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Background: Polymorphisms at the glutathione S-transferase (GST) were associated with asthma-related phenotypes. We hypothesized that the GSTP1 and GSTM1 genotypes could modify the effects of household environmental tobacco smoke (ETS) on childhood wheezing illness. Methods: We conducted a case-control study comprised of 216 lifetime wheezing children and 185 nonwheezing controls, all of whom were selected from 2524 fourth- to ninth-grade school children in southern Taiwan. Results: Homozygous GSTP1 Ile-105 was significantly associated with current wheezing (OR = 1.78, 95% CI 1.04-3.12), but insignificantly associated with ever wheezing (OR = 1.26, 95% CI 0.82-1.94). The risks of ever or current wheezing on GSTM1 null genotype were positive but not statistically significant. Although household ETS exposure was not associated with wheezing illness, after excluding subjects having in utero ETS or active smoking habits, the adverse effects of household ETS exposure differed significantly by GSTP1-105 genotypes. In children without any ETS exposure at home, GSTP1 Ile-105 homozygosity was significantly related to increased risks for both ever wheezing (OR = 2.29, 95% CI 1.17-4.49) and current wheezing (OR = 4.86, 95% CI 1.86-12.70). In children with household ETS exposure, the risks of wheezing illness did not increase for those carrying two GSTP1 Ile-105 alleles. Children carrying any GSTP1 Val-105 allele were at a significantly greater risk of both ever and current wheezing when exposed to ETS, with a clear dose-response relationship to the number of smokers at home. Conclusion: Household ETS exposure is a modifiable cause of wheezing illness in a genetically susceptible subpopulation.
机译：背景：谷胱甘肽S-转移酶（GST）的多态性与哮喘相关的表型有关。我们假设GSTP1和GSTM1基因型可以改变家庭环境烟草烟雾（ETS）对儿童喘息性疾病的影响。方法：我们进行了一项病例对照研究，该研究由216名终生喘息儿童和185名无喘息控制者组成，他们全部来自台湾南部2524名4至9年级的学童。结果：纯合子GSTP1 Ile-105与当前喘息显着相关（OR = 1.78，95％CI 1.04-3.12），但与曾经喘息无关（OR = 1.26，95％CI 0.82-1.94）。 GSTM1基因型无效或曾经喘息的风险为阳性，但无统计学意义。尽管家庭ETS暴露与喘息疾病无关，但在排除具有子宫内ETS或活跃吸烟习惯的受试者后，GSTP1-105基因型对家庭ETS暴露的不利影响显着不同。对于在家中没有任何ETS暴露的儿童，GSTP1 Ile-105纯合性与曾经喘息（OR = 2.29，95％CI 1.17-4.49）和当前喘息（OR = 4.86，95％CI 1.86-12.70）的风险增加显着相关。 ）。对于有家庭ETS暴露的儿童，携带两个GSTP1 Ile-105等位基因的儿童患喘息的风险并未增加。携带任何GSTP1 Val-105等位基因的儿童，在暴露于ETS时，有一次和现在发生喘息的风险大大增加，并且与在家中吸烟者的剂量-反应关系明确。结论：家庭ETS暴露是遗传易感人群中喘息病的一种可改变原因。

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