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Asthma score: predictive ability and risk factors.

机译：哮喘评分：预测能力和危险因素。

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Background: Definition of asthma as a continuous score is a promising tool for population studies that has not yet been fully evaluated. Objective: We assessed (i) the predictive ability of an asthma score against the occurrence of different asthma-related outcomes and (ii) the risk factors identified when using an asthma score. Methods: The European Community Respiratory Health Study II included subjects from the general population randomly studied during 1991-1993 who were followed up in the years 1998-2001, from 29 centres in 14 countries. A total of 8956 subjects were included. The asthma score consisted of a simple sum of the positive answers to five respiratory symptoms. Results: Asthma score at baseline showed a linear relationship with incidence of asthma, the occurrence of asthma attacks, use of asthma medication and bronchial reactivity at the end of the follow-up. Asthma score at the end of follow-up was associated with known risk factors at baseline such as IgE to grass, rhinitis or body mass index, in addition to passive smoking in men [average score ratio (RR) = 1.30; 95% confidence interval (CI) 1.09-1.50] or changes in body mass index (RR = 1.27; 95% CI 1.05-1.27, per each kg/m(2)). Conclusion: The asthma score had good predictive ability against outcomes related with asthma and also good ability to detect risk factors. This encourages the use of the score as a measure of asthma in epidemiological studies on aetiology of asthma.
机译：背景：将哮喘定义为连续评分是尚未得到充分评估的有希望的人群研究工具。目的：我们评估（i）哮喘评分对不同哮喘相关结局的发生的预测能力，以及（ii）使用哮喘评分时确定的危险因素。方法：欧洲共同体呼吸健康研究II包括来自1991-1993年的普通人群的受试者，这些受试者在14个国家的29个中心进行了1998-2001年的随访。总共纳入了8956名受试者。哮喘评分包括对五个呼吸道症状的肯定答案的简单总和。结果：随访结束时，基线哮喘评分与哮喘的发生率，哮喘发作的发生，哮喘药物的使用和支气管反应性呈线性关系。随访结束时的哮喘评分与基线时已知的危险因素有关，例如男性的IgE，草地炎，鼻炎或体重指数，以及被动吸烟者[平均评分比（RR）= 1.30; 95％置信区间（CI）1.09-1.50]或体重指数的变化（RR = 1.27; 95％CI 1.05-1.27，每千克/平方米（2））。结论：哮喘评分对与哮喘有关的结局具有良好的预测能力，并且具有检测危险因素的良好能力。这鼓励在哮喘病因学的流行病学研究中将该分数用作哮喘的量度。

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