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Pathophysiological mechanisms of exercise-induced anaphylaxis: an EAACI position statement

机译:运动性过敏反应的病理生理机制:EAACI立场声明

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This document is the result of a consensus on the mechanisms of exercise-induced anaphylaxis (EIAn), an unpredictable and potentially fatal syndrome. A multidisciplinary panel of experts including exercise physiologists, allergists, lung physicians, paediatricians and a biostatistician reached the given consensus. Exercise-induced anaphylaxis (EIAn) describes a rare and potentially fatal syndrome in which anaphylaxis occurs in conjunction with exercise. The pathophysiological mechanisms underlying EIAn have not yet been elucidated although a number of hypotheses have been proposed. This review evaluates the validity of each of the popular theories in relation to exercise physiology and immunology. On the basis of this evidence, it is concluded that proposed mechanisms lack validity, and it is recommended that a global research network is developed with a common approach to the diagnosis and treatment of EIAn in order to gain sufficient power for scientific evaluation.
机译:该文件是关于运动诱发的过敏反应(EIAn)(一种无法预测的并可能致命的综合征)的机制达成共识的结果。由运动生理学家,过敏症专家,肺科医生,儿科医生和生物统计学家组成的多学科专家小组达成了共识。运动诱发的过敏反应(EIAn)描述了一种罕见的,可能致命的综合症,其中与运动结合发生过敏反应。尽管提出了许多假设,但尚未阐明EIAn的病理生理机制。这篇评论评估了有关运动生理学和免疫学的每种流行理论的有效性。根据这些证据,可以得出结论,提出的机制缺乏有效性,建议使用通用的方法来开发EIAn的诊断和治疗方法,以建立一个全球研究网络,以便获得足够的科学评估能力。

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