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首页> 外文期刊>Allergy >Predictors of response to bronchial allergen challenge in 5- to 6-year-old atopic children.
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Predictors of response to bronchial allergen challenge in 5- to 6-year-old atopic children.

机译：5至6岁的特应性儿童对支气管过敏原激发反应的预测因子。

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BACKGROUND: The relationship between atopy and bronchial allergy in young children is not completely understood. OBJECTIVE: To examine the association between response to bronchial allergen challenge, immune markers of atopy and other clinical characteristics in 5- to 6-year-old children. METHODS: Children with positive skin test (SPT) to aeroallergen, together with a proportion of SPT negative children (as controls), were recruited from a birth cohort of 198 children at high risk of developing atopic disease and underwent allergen challenge. RESULTS: Thirty-seven children (26 atopic and 11 SPT negative), median age 74.5 months, were challenged: 31 with house dust mite and six with grass allergen. Only atopic children responded to challenge: n = 12/26 (46%). Wheal size [odds ratio (OR) 2.5 (1.2-5.3), P = 0.01], allergen-specific immunoglobulin E (IgE) [OR 3.4 (1.23-9.61), P = 0.02], total IgE [OR 8.6 (1.1-68.7), P = 0.04], current wheeze [OR 12 (1.7-81.7), P = 0.006] and persistent eczema [OR 11.0 (1.7-68.3), P = 0.006] emerged as the strongest independent predictors of response to allergen challenge. Prediction of response to allergen challenge was significantly improved when immune markers of atopy, and in particular wheal size, were combined with clinical characteristics. CONCLUSION: The relationship between atopy and bronchial allergy is quantitative at this age. There may be potential to create more powerful indicators of the presence of respiratory allergy in young children when immunological markers of atopy are considered quantitatively and when combined with clinical history of coexistent allergic disease.
机译：背景：特应性疾病与年幼的儿童支气管过敏之间的关系尚未完全了解。目的：探讨5至6岁儿童对支气管过敏原激发反应，特应性免疫标记物和其他临床特征之间的关系。方法：从198名出生时患有特应性疾病高风险并经历了过敏原攻击的儿童的出生队列中，招募了对空气过敏原具有阳性皮肤测试（SPT）的儿童，以及一定比例的SPT阴性儿童（作为对照）。结果：中位年龄74.5个月的三十七名儿童（26名特应性和11例SPT阴性）受到了攻击：31名患有屋尘螨，六名患有草过敏原。只有特应性儿童对挑战做出了反应：n = 12/26（46％）。鲸鱼大小[比值比（OR）2.5（1.2-5.3），P = 0.01]，过敏原特异性免疫球蛋白E（IgE）[OR 3.4（1.23-9.61），P = 0.02]，总IgE [OR 8.6（1.1- 68.7），P = 0.04]，当前的喘息[OR 12（1.7-81.7），P = 0.006]和持续性湿疹[OR 11.0（1.7-68.3），P = 0.006]成为对过敏原挑战反应的最强独立预测因子。当过敏反应的免疫标志物，特别是风团大小，与临床特征相结合时，对过敏原激发反应的预测得到了显着改善。结论：在这个年龄，特应性疾病与支气管过敏的关系是定量的。当定量地考虑特应性的免疫学标记并结合并存变态反应性疾病的临床病史时，可能会创造出更强有力的指示幼儿呼吸道过敏的指标。

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