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首页> 外文期刊>Allergy >Extent, patterns, and burden of uncontrolled disease in severe or difficult-to-treat asthma.
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Extent, patterns, and burden of uncontrolled disease in severe or difficult-to-treat asthma.

机译：在严重或难以治疗的哮喘中无法控制的疾病的程度，类型和负担。

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Background: Characterization of uncontrolled asthma burden in a natural treatment setting can influence treatment recommendations and clinical practice. The objective was to characterize and compare the economic burden of severe or difficult-to-treat asthma in uncontrolled and controlled patients. Methods: Baseline patient data (age >/= 13 years; n = 3916) were obtained from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens study. Disease control was assessed using two approaches: (i) applying criteria for control based on the Gaining Optimal Asthma ControL study, and (ii) using the Asthma Therapy Assessment Questionnaire (ATAQ) to identify the number of asthma control problems. Assessments were performed at baseline, and at months 12 and 24. Monetary values were assigned to productivity loss and medical resource use. Direct and indirect costs were aggregated over 24 months and compared using Student's t-test for continuous measures and chi-squared for categorical variables. Results: Throughout the study, most patients had uncontrolled asthma (83% uncontrolled; 16% inconsistent control; 1.3% controlled). Controlled patients experienced fewer work or school absences and less healthcare resource use than uncontrolled patients at all study time points. Using the multilevel ATAQ control score, asthma costs increased directly with the number of asthma control problems. Costs for uncontrolled patients were more than double those of controlled patients throughout the study (Dollars 14 212 vsDollars 6452; adjusted to 2002 dollars; P < 0.0001). Conclusions: This study demonstrated that few severe or difficult-to-treat asthma patients achieved control over a 2-year period and the economic consequence of uncontrolled disease is substantial.
机译：背景：在自然治疗中无法控制的哮喘负担特征可能会影响治疗建议和临床实践。目的是表征和比较不受控制和控制的患者中严重或难以治疗的哮喘的经济负担。方法：从《流行病学和哮喘自然史：结果和治疗方案》研究中获得基线患者数据（年龄> / = 13岁; n = 3916）。使用两种方法评估疾病控制：（i）根据获得的最佳哮喘控制研究应用控制标准，以及（ii）使用哮喘治疗评估问卷（ATAQ）来确定哮喘控制问题的数量。在基线以及第12和24个月进行评估。将货币价值分配给生产力损失和医疗资源使用。直接和间接费用在24个月内汇总，并使用Student t检验比较连续量度，对卡方进行分类变量比较。结果：在整个研究过程中，大多数患者患有不受控制的哮喘（83％无法控制; 16％不一致的控制; 1.3％受控）。在所有研究时间点，与非对照患者相比，对照患者经历的工作或学校缺勤次数更少，医疗资源的使用更少。使用多级ATAQ控制评分，哮喘成本随哮喘控制问题的数量而直接增加。在整个研究中，非对照患者的费用是对照患者的两倍以上（美元14 212 vs美元6452;调整为2002年美元; P <0.0001）。结论：这项研究表明，很少有重症或难治性哮喘患者在2年内获得控制，不受控制的疾病的经济后果是巨大的。

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