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首页> 外文期刊>Allergy >Excess subcutaneous tissue may preclude intramuscular delivery when using adrenaline autoinjectors in patients with anaphylaxis
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Excess subcutaneous tissue may preclude intramuscular delivery when using adrenaline autoinjectors in patients with anaphylaxis

机译：过敏反应患者使用肾上腺素自动注射器时，皮下组织过多可能会阻止肌肉内递送

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Intramuscular adrenaline is the gold standard treatment for anaphylaxis. Intramuscular injection provides more rapid and higher plasma concentrations than subcutaneous routes. Given the increasing epidemic of obesity patients are at increased risk of subcutaneous delivery, we therefore assessed the depth of subcutaneous tissue in a population of patients with anaphylaxis. Patients already prescribed adrenaline autoinjectors (AAIs) for anaphylaxis were examined with ultrasound, and measurements of skin-to-muscle depth (STMD) at anterolateral thigh and anterior thigh were performed. Twenty-eight patients (23 female, 5 male) with an age range of 18-75 took part in the study, and in 68%, the STMD was greater than AAI needle length (15.02mm), using the anterolateral thigh as the recommended administration site. The key predictors for increased STMD were female gender (P=0.0003) and a BMI>30 (P=0.04). AAIs require longer needles to ensure intramuscular administration, and ultrasound at point of prescription would aid needle length selection.
机译：肌注肾上腺素是过敏性反应的金标准治疗方法。肌内注射比皮下途径提供更快和更高的血浆浓度。鉴于肥胖症的流行病患者皮下分娩的风险增加，因此我们评估了过敏反应患者皮下组织的深度。对已经开具肾上腺素自动注射剂（AAI）进行过敏性反应的患者进行超声检查，并测量大腿前外侧和大腿前部的皮肤肌肉深度（STMD）。推荐年龄在18-75岁的28位患者（23位女性，5位男性），并且68％的STMD大于AAI针长度（15.02mm），推荐使用大腿外侧管理站点。 STMD升高的主要预测指标是女性（P = 0.0003）和BMI> 30（P = 0.04）。 AAI需要更长的针头以确保肌肉内给药，而处方时的超声检查将有助于选择针头长度。

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