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The locus C11orf30 increases susceptibility to poly-sensitization

机译：C11orf30基因座增加了对多敏化的敏感性

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A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the large multicentre population-based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly-sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR=1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR=2.27, 95% CI 1.34-3.95). The association of rs2155219 with higher levels of expression of C11orf30, which may be involved in transcription repression of interferon-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.
机译：许多遗传变异与变态反应致敏有关，但是这些变体是过敏原特异的还是对多敏化的敏感性增加尚不清楚。使用基于大型多中心人群的欧洲共同体呼吸健康调查的数据，我们评估了10个基因座与特定IgE和皮肤点刺试验与个体过敏原和多敏化之间的关联。我们发现这10个基因座以非特异性方式与对不同变应原的致敏有关，特别是C11orf30-rs2155219使多致敏的风险加倍（特异性IgE / 4致敏原：OR = 1.81，95％CI 0.80-4.24 ;皮肤点刺试验/ 4 +过敏原：OR = 2.27，95％CI 1.34-3.95）。 rs2155219与C11orf30较高表达水平的关联可能与干扰素刺激基因的转录抑制有关，并且其与多种过敏原的敏化关联表明该位点与特应性高度相关。

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