Intrinsic properties of germinal center-derived B cells promote their enhanced class switching to IgE

Ramadani F.; Upton N.; Hobson P.; Chan Y. -C.; Mzinza D.; Bowen H.; Kerridge C.; Sutton B. J.; Fear D. J.; Gould H. J.

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Intrinsic properties of germinal center-derived B cells promote their enhanced class switching to IgE

机译：生发中心衍生的B细胞的内在特性促进其向IgE的增强类别转换

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Background: Research on the origins and development of human IgE-expressing (IgE(+)) cells is required for understanding the pathogenesis of allergy and asthma. These studies have been thwarted by the rarity of IgE(+) cells in vivo and the low frequency of class switch recombination (CSR) to IgE ex vivo. To determine the main source of IgE(+) cells, we investigated the relation between the phenotypic composition of tonsil B cells and the CSR to IgE ex vivo.

机译：背景：研究人类表达IgE（IgE（+））的细胞的起源和发展是了解变态反应和哮喘的发病机制所必需的。这些研究由于体内IgE（+）细胞的稀少性和离体至IgE的分类开关重组（CSR）频率低而受到阻碍。为了确定IgE（+）细胞的主要来源，我们调查了扁桃体B细胞表型组成与离体IgE的CSR之间的关系。

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《Allergy》 |2015年第10期|共9页
作者
Ramadani F.; Upton N.; Hobson P.; Chan Y. -C.; Mzinza D.; Bowen H.; Kerridge C.; Sutton B. J.; Fear D. J.; Gould H. J.;
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正文语种 eng
中图分类医学免疫学;
关键词
allergy; germinal center; human B cells; IgE class switching;

机译：变态反应;生殖中心;人B细胞;IgE类别转换;

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1. Intrinsic properties of germinal center-derived B cells promote their enhanced class switching to IgE [J] . Ramadani F., Upton N., Hobson P., Allergy . 2015,第10期

机译：生发中心衍生的B细胞的内在特性促进其向IgE的增强类别转换
2. Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells. [J] . Engels N, Konig LM, Heemann C Nature immunology . 2009,第9期

机译：将细胞质衔接子Grb2募集至表面IgG和IgE，可为类转换B细胞提供抗原受体内在共刺激。
3. B cell–Intrinsic MyD88 signaling promotes initial cell proliferation and differentiation to enhance the germinal center response to a virus-like particle [J] . Tian, M.a, Hua, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2018,第3期

机译：B细胞内在MyD88信号传导促进初始细胞增殖和分化，以增强生发中心对病毒样颗粒的反应
4. Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells [C] . Paul J. Bryce, Mendy L. Miller, Ichiro Miyajima, Symposium on Mast Cells and Basophils: Development, Activation and Roles in Allergic/Autoimmune Disease . 2005

机译：皮肤中的免疫敏化通过抗原对肥大细胞的抗原无关作用而增强
5. T Follicular Regulatory Cells Promote the Germinal Center Reaction and Allergic IgE Response While Repressing Abnormal Differentiation of T Follicular Helper Cells [D] . Xie, Ming. 2019

机译：T卵泡调节细胞促进生发中心反应和过敏性IgE反应，同时抑制T卵泡辅助细胞的异常分化
6. Intrinsic properties of germinal center‐derived B cells promote their enhanced class switching to IgE [O] . F. Ramadani, N. Upton, P. Hobson, -1

机译：生发中心衍生的B细胞的内在特性促进其向IgE转换的增强类别
7. The immunoglobulin tail tyrosine of membrane-bound IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched memory B cells [O] . Wienands J, Schrader V, Griep S, 2009

机译：膜结合的IgG和IgE的免疫球蛋白尾酪氨酸为类切换记忆B细胞提供抗原受体固有共刺激

Intrinsic properties of germinal center-derived B cells promote their enhanced class switching to IgE

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