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Phenotypes and endotypes of rhinitis and their impact on management: a PRACTALL report

机译：鼻炎的表型和内型及其对管理的影响：实践报告

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Rhinitis is an umbrella term that encompasses many different subtypes, several of which still elude complete characterization. The concept of phenotyping, being the definition of disease subtypes on the basis of clinical presentation, has been well established in the last decade. Classification of rhinitis entities on the basis of phenotypes has facilitated their characterization and has helped practicing clinicians to efficiently approach rhinitis patients. Recently, the concept of endotypes, that is, the definition of disease subtypes on the basis of underlying pathophysiology, has emerged. Phenotypes/endotypes are dynamic, overlapping, and may evolve into one another, thus rendering clear-cut definitions difficult. Nevertheless, a phenotype-/endotype-based classification approach could lead toward the application of stratified and personalized medicine in the rhinitis field. In this PRACTALL document, rhinitis phenotypes and endotypes are described, and rhinitis diagnosis and management approaches focusing on those phenotypes/endotypes are presented and discussed. We emphasize the concept of control-based management, which transcends all rhinitis subtypes.
机译：鼻炎是一个笼统的术语，涵盖许多不同的亚型，其中有些仍无法完整表征。表型的概念，即基于临床表现的疾病亚型的定义，在过去的十年中已经得到了很好的确立。根据表型对鼻炎实体进行分类有助于其表征，并帮助临床医生有效地接触鼻炎患者。近来，出现了内型的概念，即基于潜在病理生理学的疾病亚型的定义。表型/内型是动态的，重叠的，并且可能彼此进化，因此很难进行清晰的定义。然而，基于表型/内型的分类方法可能会导致分层和个性化医学在鼻炎领域的应用。在此PRACTALL文件中，描述了鼻炎的表型和内型，并提出并讨论了针对这些表型/内型的鼻炎的诊断和管理方法。我们强调基于控制的管理概念，该概念超越了所有鼻炎亚型。

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