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首页> 外文期刊>Allergy >Lipopolysaccharide amplifies eosinophilic inflammation after segmental challenge with house dust mite in asthmatics
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Lipopolysaccharide amplifies eosinophilic inflammation after segmental challenge with house dust mite in asthmatics

机译：在哮喘患者中用房尘螨进行分段攻击后，脂多糖会增强嗜酸性炎症

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BackgroundHouse dust contains mite allergens as well as bacterial products such as lipopolysaccharide (LPS). Asthma exacerbations are associated with the level of exposure to allergens and LPS. LPS can potentiate allergen effects in steroid-naive patients. Long-acting 2-agonists (LABA) were shown to inhibit LPS-induced bronchial inflammation in healthy volunteers. The aim of this study was to assess the effect of LPS on the allergen-induced eosinophilic inflammation [primary endpoints: eosinophil counts and eosinophil cationic protein (ECP)] induced by bronchial instillation of house dust mite (HDM) in patients with asthma on maintenance treatment with inhaled corticosteroids (ICS).
机译：背景房屋的灰尘中含有螨过敏原以及细菌性产品，例如脂多糖（LPS）。哮喘恶化与过敏原和LPS的暴露水平有关。 LPS可以在未接受类固醇的患者中增强变应原作用。长效2-激动剂（LABA）在健康志愿者中可抑制LPS诱导的支气管炎症。这项研究的目的是评估LPS对哮喘患者维持性支气管滴注房尘螨（HDM）诱导的变应原诱导的嗜酸性粒细胞炎症[主要终点：嗜酸性粒细胞计数和嗜酸性粒细胞阳离子蛋白（ECP）]的影响吸入皮质类固醇（ICS）治疗。

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