Airway responsiveness to mannitol 24h after allergen challenge in atopic asthmatics

Davis B. E.; Amakye D. O.; Cockcroft D. W.

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Airway responsiveness to mannitol 24h after allergen challenge in atopic asthmatics

机译：过敏性哮喘患者过敏原激发后24h的气道对甘露醇的反应性

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BackgroundAirway responsiveness to indirect stimuli correlates positively with airway inflammation. In atopic asthmatics, allergen inhalation is associated with an influx of inflammatory cells and increased responsiveness to the direct-acting stimuli methacholine at 3 and 24h after exposure. We have shown mannitol responsiveness decreases 3h after allergen inhalation. The current investigation assessed mannitol responsiveness 24h after allergen challenge.

机译：背景技术气道对间接刺激的反应性与气道炎症呈正相关。在特应性哮喘中，吸入过敏原与炎症细胞大量涌入和暴露后3和24小时对直接作用的乙酰甲胆碱的反应性增强有关。我们已经显示，吸入过敏原后3h甘露醇反应性下降。目前的研究评估了过敏原激发后24h的甘露醇反应性。

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《Allergy》 |2015年第6期|共7页
作者
Davis B. E.; Amakye D. O.; Cockcroft D. W.;
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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
allergen; asthma; mannitol; refractoriness;

机译：过敏原;哮喘;甘露醇;难治性;

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专利

1. Airway responsiveness to mannitol 24h after allergen challenge in atopic asthmatics [J] . Davis B. E., Amakye D. O., Cockcroft D. W. Allergy . 2015,第6期

机译：过敏性哮喘患者过敏原激发后24h的气道对甘露醇的反应性
2. CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge [J] . C. Pilette, J.N. Francis, S.J. Till, The European respiratory journal : . 2004,第6期

机译：分段过敏原激发后，CCR4配体在特应性哮喘患者的气道中上调
3. Increased Numbers of Both Airway Basophils and Mast Cells in Sputum after Allergen Inhalation Challenge of Atopic Asthmatics [J] . Galil M. Gauvreau, Jong M. Lee, Richard M. Watson American journal of respiratory and critical care medicine . 2000,第5期

机译：过敏性哮喘患者吸入过敏原后痰液中气道嗜碱性粒细胞和肥大细胞数量增加
4. Airway Generation-specific Remodeling, Immune and Inflammatory Cells and Cytokines in Allergen-challenged Rhesus Monkeys [C] . Dallas M. Hyde, Lisa A. Miller, Edward S. Schelegle, Annual Meeting of the American Society for Veterinary Clinical Pathology . 2006

机译：Actigen挑战性恒河猴的呼吸道特异性重塑，免疫和炎症细胞和细胞因子
5. Protective effect of H1 and CysLT1 antagonists on allergen induced airway responses in atopic asthma. [D] . Davis, Beth. 2009

机译：H1和CysLT1拮抗剂对过敏原诱导的特应性哮喘气道反应的保护作用。
6. Lung parenchymal and airway changes on CT imaging following allergen challenge and bronchoalveolar lavage in atopic and asthmatic subjects [O] . Dexter P. Mendoza, Puja Kohli, John W. Nance, 2020

机译：肺实质和气道对Atopic和哮喘受试者的过敏原挑战和支气管肺泡灌洗后CT成像的变化
7. CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge [O] . Pilette, C, Francis, J N, Till, S J, 2004

机译：分段过敏原激发后，CCR4配体在特应性哮喘患者的气道中上调

Airway responsiveness to mannitol 24h after allergen challenge in atopic asthmatics

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