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首页> 外文期刊>感染症学雑誌 >In vitro activity of methylrosaniline chloride (gentian violet) as disinfectant against Candida spp. and Trichosporon spp. isolated from blood samples
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In vitro activity of methylrosaniline chloride (gentian violet) as disinfectant against Candida spp. and Trichosporon spp. isolated from blood samples

机译：甲基氯烷氯化物（龙胆紫）的体外活性作为对念珠菌SPP的消毒剂。 和Trichosporon SPP。 与血样隔离

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OBJECTIVE: Methylrosaniline Chloride (MRC) is recognized as a disinfectant, but recently is rarely used in the clinic, because of its cytotoxicity when used continuously with conventional concentrations (1% MRC). We have reported the antibacterial activity of MRC with lower concentration against Methicillin-resistant Staphylococcus aureus (MRSA). In this study, we evaluated the antifungal activity of MRC with lower concentrations. MATERIAL AND METHODS: Antifungal activities of MRC against Candida spp. and Trichosporon spp. were tested. All strains tested were isolated from 106 blood or intravenous catheter samples at Juntendo University Hospital from 1995 to 2004. Minimum inhibitory concentrations against fungi were assayed by agar dilution, under both aerobic and anaerobic conditions. RESULTS: A 0.01% or less concentration of MRC solutions showed marked antifungal activity against Candida spp. and Trichosporon spp. under aerobic or anaerobic conditions. CONCLUSION: A 0.01% or less concentration of MRCshould be reevaluated for the control of fungal infection and MRSA infection control.
机译：目的：甲基氯氰胺氯化物（MRC）被认为是消毒剂，但最近在临床中很少使用，因为其具有常规浓度（1％MRC）连续使用的细胞毒性。我们已经报道了MRC的抗菌活性，抗甲氧西林耐金黄色葡萄球菌（MRSA）。在该研究中，我们评估了MRC的抗真菌活性以较低的浓度。材料与方法：MRC对Candida SPP的抗真菌活动。和Trichosporon SPP。经过测试。从1995年到2004年，在爪子内大学医院的106家血液或静脉内导管样本中分离出所有的菌株。通过琼脂稀释，在有氧和厌氧条件下，通过琼脂稀释来测定对真菌的最小抑制浓度。结果：0.01％以下的MRC溶液浓度显示出对念珠菌SPP的显着抗真菌活性。和Trichosporon SPP。在有氧或厌氧条件下。结论：MRC应重新评估了0.01％或更少的MRC浓度以控制真菌感染和MRSA感染控制。

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