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首页> 外文期刊>感染症学雑誌 >Cytotoxic effect and influence of povidone-iodine on wounds in guinea pig
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Cytotoxic effect and influence of povidone-iodine on wounds in guinea pig

机译：povidone-碘对豚鼠伤口的细胞毒性作用及影响

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Cytotoxicity and effect on guinea pig wounds were compared with three kinds of 10% povidone-iodine solution (isodine, neojodine, J-iodine) and povidone-iodine. It gave the following results: 1. In the Chang conjunctiva cell where remarkable toxicity was observed in the used cell line, the toxicity emphasized was 10 times using povidone-iodine < J-iodine < neojodine < isodine. In addition, a toxic difference was recognized between cells, in the order of Chang conjunctiva > SIRC > FRSK > human fibroblast for isodine and neojodine. 2. As for the influence on cells achromatized in sodium thiosulfate, alteration was not recognized in isodine, J-iodine using half-maximum cytotoxicity concentrations (CC50), and, in neojodine and povidone-iodine, elimination of drug toxicity was recognized in Chang conjunctiva/FRSK cells. 3. Strong toxicity was seen in isodine and neojodine in the toxicity test using colony formation method, however on washing with PBS (-), an easing of the toxicity effect could be seen to 0.01%. 4. Polyoxythylene nonylphenyl ether, NP-10 was the most toxic in the used surfactants in this study, and the toxicity by 100 times when compared with sodium polyoxyethylene lauryl ether sulfate, SBL-2N. Prominent sensitivity was observed in Chang conjunctiva cells with regard to the cell line and subsequently showed toxicity in order of SIRC > FRSK > human fibroblast. Remarkably, the difference between solutions of isodine and J-iodine was made more clear from the 5th culture. 5. In this study, significantly guinea pig wounds, povidone-iodine blocked all examples significantly recognized as dallying by distance between epidermal cells. In addition, isodine was meaningful area. Although their ware not offer the significant differences, the solutions obstructed the sliding of epidermal cells in comparison with povidone-iodine, and a delaying tendency of inflammation was also recognized. The toxic difference between povidone iodine solutions was regarded as the influence of surfactants added to the povidone-iodine. Based on this foundation study, more detailed clinical testing is necessary in determine where sterilization to wounds/mucosa/eyes with solutions containing additive is a suitable panpractice or not.
机译：将豚鼠伤口的细胞毒性和对豚鼠伤口的影响与三种10％聚吡啶 - 碘溶液（Isodine，Neojodine，J-碘）和povidone-碘进行比较。它给出了以下结果：1。在使用过型​​细胞系中观察到显着毒性的Chang结膜细胞中，使用Povidone-碘 SIRC> FRSK> ISODIN和Neojodine的人成纤维细胞。 2.对于对硫代硫酸钠硫酸钠的细胞的影响，使用半高和毒性浓度（CC50）在Isodine，J-Iodine中识别出改变，并且在新加丁和Povidone-碘中，在Chang中发现了消除药物毒性的毒性结膜/ FRSK细胞。 3.使用菌落形成方法在毒性试验中观察到Isodine和Neojodine的强烈毒性，但是在用PBS（）洗涤时，可以将毒性效果的缓和可见为0.01％。 4.聚氧基壬烯壬基醚，NP-10是本研究中使用过的表面活性剂中最有毒的，与氧化氢氧乙烯月桂基醚硫酸钠，SBL-2N相比，毒性100倍。在Cheng结膜细胞中观察到突出的敏感性关于细胞系，随后向SIRC> FRSK>人成纤维细胞的顺序显示毒性。值得注意的是，从第5型培养物中澄清了Isodine和J-碘的溶液之间的差异。 5.在本研究中，显着的豚鼠伤口，PoVidone-碘阻断所有实例通过表皮细胞之间的距离显着认识到Dallying。此外，Isodine是有意义的。虽然它们的洁具没有提供显着的差异，但是与Povidone-碘相比，解决方案阻碍了表皮细胞的滑动，并且还认识到炎症的延迟趋势。将POOMIDONE碘溶液之间的有毒差异被认为是加入的表面活性剂的影响加入到POVIDONE - 碘中。基于该基础研究，更详细的临床测试是必要的，以确定对含有添加剂溶液的伤口/粘膜/眼睛的灭菌是合适的Panpractice。

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