We describe the pattern of sensitisation to pet IgE components and its association with clinical symptoms. Hundred and fifty nine consecutive patients with rhinitis/asthma sensitised to dog, cat, and horse were recruited. Specific IgE to whole extracts and to pet recombinant allergens were performed. Only 5% of patients were monosensitised to animal allergens. Specific IgE to Can f 1 was significantly associated with persistent rhinitis, Can f 2 with asthma diagnosis, Can f 3 with moderate/severe rhinitis (M/S-R) and asthma diagnosis (AD), and Can f 5 with persistent and M/S-R. Positive IgE to Fel d 2 was significantly associated with M/S-R and AD, Equ c 1 with M/S-R and Equ c 3 with persistent rhinitis, AD and severe asthma. Sensitisation to >= 2 molecules or to pet albumins was associated with more severe respiratory symptoms. Molecular diagnosis in patients with pet allergy may also help clinicians to predict clinical symptoms and their severity.
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机译：我们描述了对宠物IgE成分及其与临床症状的关联的致敏模式。招募了59例连续的对狗，猫和马敏感的鼻炎/哮喘患者。对整个提取物和宠物重组过敏原进行了特异性IgE。仅5％的患者对动物过敏原单敏。 Can f 1的特异性IgE与持续性鼻炎，Can f 2与哮喘的诊断，Can f 3与中/重度鼻炎（M / SR）和哮喘诊断（AD）以及Can f 5与持续性和M / SR显着相关。 Fel d 2的阳性IgE与M / S-R和AD显着相关，Equ c 1与M / S-R和Equ c 3与持续性鼻炎，AD和严重哮喘相关。对> = 2个分子或宠物白蛋白的过敏与更严重的呼吸道症状有关。宠物过敏患者的分子诊断还可帮助临床医生预测临床症状及其严重程度。
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