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首页> 外文期刊>臨床病理 >Plasma levels of soluble fibrin in patients with disseminated intravascular coagulation
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Plasma levels of soluble fibrin in patients with disseminated intravascular coagulation

机译：促进血管内凝血患者可溶性纤维蛋白的血浆水平

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摘要

Soluble fibrin(SF) is formed in the early-activated state of blood coagulation and quantitative measurement of SF shows high potential as a parameter for the diagnosis of suspected disseminated intravascular coagulation(DIC). The aim of the present study is to evaluate the usefulness of a newly developed SF test utilizing SF specific monoclonal antibody(F405). Among hemopoietic and non-hemopoietic tumor patients, 249 patients with suspected DIC were collected. The SF level showed a good correlation with the DIC score and the SF levels in DIC patients were significantly higher than those in s-DIC and pre-DIC patients. Receiver operating characteristic(ROC) analysis also showed that the specificity and sensitivity of the SF assay were higher than those of thrombin-antithrombin complex(TAT). In conclusion, these results indicate that the SF assay is a highly precise method for the diagnosis and screening of DIC stages.
机译：在早期激活的早期血液凝血状态下形成可溶性纤维蛋白（SF），SF的定量测量显示出高潜力作为诊断涉嫌血管内凝血（DIC）的参数。 本研究的目的是评估利用SF特异性单克隆抗体（F405）进行新开发的SF试验的有用性。 在血细胞和非血气肿瘤患者中，收集249例怀疑DIC的患者。 SF水平显示出与DIC评分的良好相关性，DIC患者的SF水平明显高于S-DIC和DIC患者的SF水平。 接收器操作特征（ROC）分析还表明，SF测定的特异性和敏感性高于凝血酶 - 抗凝血酶复合物（TAT）的特异性和敏感性。 总之，这些结果表明SF测定是一种高精度的诊断和筛选DIC阶段的方法。

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