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首页> 外文期刊>ACS applied materials & interfaces >Manganese-Loaded Dual-Mesoporous Silica Spheres for Efficient T1-and T2-Weighted Dual Mode Magnetic Resonance Imaging
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Manganese-Loaded Dual-Mesoporous Silica Spheres for Efficient T1-and T2-Weighted Dual Mode Magnetic Resonance Imaging

机译：锰负载双介孔二氧化硅球体，用于高效的T1和T2加权双模磁共振成像

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摘要

A novel class of manganese-based dual-mode contrast agents (DMCAs) based on the core—shell structured manganese-loaded dual-mesoporous silica spheres (Mn-DMSSs) for simultaneous T1- and T2-weighted magnetic resonance imaging (MRI) has been successfully reported. The in vitro MR tests demonstrate that the Mn-based DMCAs display an excellent simultaneous T1-weighted and T2-weighted MR imaging effect with a noticeably high Tl relaxivity (r1) of 10.1 mM~(-1) and a moderately high T2 relaxivity (r2) of 169.7 mM~(-1)s~(-1). The Mn-based DMCAs exhibit negligible cytotoxicity with >80% cell viability at a concentration of up to 200 μg/mL in human liver carcinoma (HepG2) and mouse macrophage (RAW264.7) cells after 24 h. Confocal laser scanning microscopy (CLSM) results show that the Mn-DMSSs were internalized via endocytosis and located in the cytoplasm but not in the nucleus. The in vivo experiment shows that the signals of rat liver increased by 29% under T1-weighted imaging mode and decreased by 28% under T2-weighted imaging mode in 5 min postinfection of Mn-DMSSs, which reveal that the novel Mn-loaded DMSSs can be used as both positive (T1-weighted) and negative (T2-weighted) MR contrast agents in further biomedical applications.
机译：基于核-壳结构的负载锰的双介孔二氧化硅球（Mn-DMSS）的新型一类基于锰的双模造影剂（DMCA）用于同时进行T1和T2加权磁共振成像（MRI）已成功报告。体外MR测试表明，基于Mn的DMCA具有出色的同时T1加权和T2加权MR成像效果，T1弛豫度（r1）为10.1 mM〜（-1），并且T2弛豫度中等（ r2）为169.7 mM〜（-1）s〜（-1）。 24小时后，在人肝癌（HepG2）和小鼠巨噬细胞（RAW264.7）细胞中，浓度高达200μg/ mL时，基于Mn的DMCA的细胞毒性可忽略不计，细胞活力> 80％。共聚焦激光扫描显微镜（CLSM）结果表明，Mn-DMSS通过内吞作用而被内在化，并且位于细胞质中而不位于细胞核中。体内实验表明，在Mn-DMSSs感染后5分钟内，在T1加权成像模式下大鼠肝脏的信号增加了29％，在T2加权成像模式下减少了28％，这表明新型的Mn加载的DMSS可以在其他生物医学应用中同时用作正（T1加权）和负（T2加权）MR造影剂。

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