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Effectiveness of oral vitamin B12 therapy for pernicious anemia and vitamin B12 deficiency anemia

机译：口服维生素B12治疗对恶性贫血和维生素B12缺乏症的有效性

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We investigated the efficacy of oral vitamin B12 (B12) therapy in patients with B12-deficiency anemia. Between June 1994 and June 2000, 17 patients, who were diagnosed as having B12-deficiency anemia and gave their informed consent, were enrolled in this study. Of these patients, 7 were further treated with a maintenance dose of methylcobalamin (1,500 micrograms daily for 7 days every 1-3 months). Correction of hematological and neurological abnormalities was prompt. The hemoglobin level and serum concentration of B12 were normalized within two months after starting the treatment. Recovery from neurological disturbance was observed within one month. To maintain a normal serum concentration of B12, a 7-day regime of administration was needed every month in 3 patients, every 2 months in 3 patients, and every 3 months in 1 patient. These results demonstrate the effectiveness of oral cobalamin therapy, and also that oral intermittent therapy is useful for maintaining a normal serum B12 concentration. Oral cobalamin therapy might be as effective as conventional injection therapy, and useful for long-term treatment.
机译：我们调查了口服维生素B12（B12）治疗在B12缺乏贫血患者中的疗效。 1994年6月至2000年6月期间，17名诊断为具有B12缺乏贫血的患者并在本研究中致力于获得知情同意。在这些患者中，通过甲基钴胺的维持剂量（每天每1-3个月每天为7天，每天为1,500微克），进一步处理7例。促进血液学和神经异常的纠正是迅速的。在开始治疗后的两个月内，B12的血红蛋白水平和血清浓度被标准化。在一个月内观察到神经系统干扰的恢复。为了保持B12的正常血清浓度，每月在3名患者中每月一次，3名患者每月一次，每3个月，1例患者每2个月都需要7天的给药制度。这些结果证明了口服钴胺治疗的有效性，并且口服间歇性治疗可用于维持正常的血清B12浓度。口服钴胺素治疗可能与常规注射治疗有效，可用于长期治疗。

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