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首页> 外文期刊>日本輸血学会雑誌: Journal of the Japan Society of Blood Transfusion >HPA-DNAタイピングによるHLA·HPA適合血小板を必要とする患者のための適合ドナープール
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HPA-DNAタイピングによるHLA·HPA適合血小板を必要とする患者のための適合ドナープール

机译:符合HLA和HPA符合HPA-DNA打字的患者的致捐助池

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摘要

HLA-HPA-immunized patients require HLA-HPA-matched platelets. We supplied HLA-HPA-matched platelets to 14 patients in which HPA of their HLA-matched donors were typed by the MPHA method. Since 1996 we have typed HPA-1, -2, -3, -4, -5, -6 of 1,705 donors (20.7%) by DNA-typing (ELMA) from 8,226 HLA-typed donors to establish an HLA-HPA-typed donor pool.Patients with anti-HPA-lb, -2b, -3a, -5b, and -Naka received HPA-matched donors in 95.2%, 75.8%, 17.7%, 91.7% and 10.0% of HPA-typed donors from their HLA-matched donors, respectively.Fourteen patients will fully receive HLA-HPA-matched donors from the present HLA-HPA-typed donor pool unless they frequently require HLA-HPA-matched platelets in long-term treatment.HLA-HPA-matched donors are determined according to the following characteristics: 1) frequency and term of patients' HLA-HPA-matched platelet transfusion 2) antigen frequency of patients' own HLA and patients' acceptable HLA 3) donors' HPA frequency.We consider we were able to establish an HLA-HPA-typed donor pool for most patients. However, if patients are not able to fully receive HLA-HPA-matched donors from the present donor pool, it will be necessary to type HPA of their HLA-matched donors more efficiently, or to cooperate with other Red Cross Blood Centers in order to supply HLA-HPA-matched platelets smoothly.
机译:HLA-HPA-免疫患者需要HLA-HPA匹配的血小板。我们将HLA-HPA匹配的血小板提供给14名患者,其中通过MPHA方法键入其HLA匹配供体的HPA。自1996年以来,通过8,226个HLA类型供体的DNA键入(ELMA),通过8,226 HLA类型的捐赠者进行键入的HPA-1,-2,-3,-4,-5,-6,为1,705个捐助者(20.7%),以建立HLA-HPA-类型供体池。具有抗HPA-LB,-2B,-3A,-5B和-NAKA的患者,收到HPA匹配的供体,75.2%,75.8%,17.7%,91.7%和10.0%的HPA类型供捐赠者他们的HLA匹配的捐助者。除非他们经常需要HLA-HPA匹配的血小板,福利患者将完全接受HLA-HPA匹配的供体,除非他们在长期治疗中经常要求HLA-HPA匹配的血小板.HLA-HPA匹配供体根据以下特征确定:1)患者HLA-HPA匹配血小板输血2的频率和期限)患者自身HLA和患者的患者的抗原频率和患者的患者的HPA频率。我们认为我们能够考虑我们能够为大多数患者建立HLA-HPA类型的供体池。但是,如果患者无法从目前的供体池完全接受HLA-HPA匹配的供体,则需要更有效地键入其HLA匹配的供体的HPA,或与其他红十字血液中心合作顺利提供HLA-HPA匹配的血小板。

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