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首页> 外文期刊>Allergy & clinical immunology international: official organ of the International Association of Allergology and Clinical Immunology >Allergic Conjunctivitis
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Allergic Conjunctivitis

机译：过敏性结膜炎

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The IgE-mast cell mediated (Type 1) allergic response is characterized by development of allergen-specific IgE antibodies that trigger an inflammatory reaction following reexposure to allergen. Interaction between allergen and mast cell-bound IgE induces early and late phase inflammation mediated by histamine, prostaglandins, leukotrienes, cytokines, chemokines, and chemotactic factors. Although mast cells are central to the inflammatory response, infiltrating leukocytes such as neutrophils, eosinophils, basophils, and T lymphocytes, also play an important role in the inflammatory cascade. IgE-mediated allergic inflammation is typically observed in allergic conditions of the eye (allergic conjunctivitis), nose (allergic rhinitis), and lungs (asthma). Intermittent (seasonal) and persistent (perennial) allergic conjunctivitis account for 95% of ocular allergies in the United States. The symptoms of allergic conjunctivitis are triggered by inflammatory mediators: Histamine induces itching, redness, waterydischarge, and conjunctival swelling, which may be exacerbated by prostaglandins and leukotrienes; cytokines and chemokines increase leukocyte infiltration, enhancing inflammation and the potential for ocular tissue injury. Although symptoms may significantly impair patients' quality of life, allergic conjunctivitis remains underdiagnosed because it is often included under the allergic rhinitis umbrella. In order to increase awareness of allergic conjunctivitis and other allergic conditions, the Nomenclature Review Committee of the World Allergy Organization (WAO) is revising nomenclature and formulating new diagnostic and treatment guidelines in conjunction with the American Academy of Allergy, Asthma, and Immunology (AAAAI) and the Association for Research in Vision and Ophthalmology (ARVO).
机译：IgE肥大细胞介导的（1型）变态反应的特征在于发展了变应原特异性的IgE抗体，其在再次暴露于变应原之后触发了炎症反应。过敏原和肥大细胞结合的IgE之间的相互作用诱导了由组胺，前列腺素，白三烯，细胞因子，趋化因子和趋化因子介导的早期和晚期炎症。尽管肥大细胞是炎症反应的核心，但浸润性白细胞（如嗜中性粒细胞，嗜酸性粒细胞，嗜碱性粒细胞和T淋巴细胞）在炎症级联反应中也起着重要作用。 IgE介导的过敏性炎症通常在眼睛（过敏性结膜炎），鼻子（过敏性鼻炎）和肺部（哮喘）的过敏性疾病中观察到。在美国，间歇性（季节性）和持续性（多年生）过敏性结膜炎占眼部过敏的95％。过敏性结膜炎的症状由炎症介质触发：组胺引起瘙痒，发红，水肿和结膜肿胀，前列腺素和白三烯可能会加重病情。细胞因子和趋化因子会增加白细胞浸润，增强炎症，并可能引起眼部组织损伤。尽管症状可能会严重损害患者的生活质量，但由于过敏性结膜炎通常包含在过敏性鼻炎保护伞下，因此仍未得到充分诊断。为了提高对过敏性结膜炎和其他过敏性疾病的认识，世界过敏组织（WAO）的命名审查委员会正在与美国过敏，哮喘和免疫学学会（AAAAI）一起修订命名并制定新的诊断和治疗指南。 ）和视觉与眼科研究协会（ARVO）。

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