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首页> 外文期刊>American Journal of Physiology >Microvascular reperfusion injury: rapid expansion of anatomic no reflow during reperfusion in the rabbit.
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Microvascular reperfusion injury: rapid expansion of anatomic no reflow during reperfusion in the rabbit.

机译：微血管再灌注损伤：家兔再灌注过程中解剖快速扩张，无回流。

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摘要

The aim was to define the degree and time course of reperfusion-related expansion of no reflow. In five groups of anesthetized, open-chest rabbits (30-min coronary occlusion and different durations of reperfusion), anatomic no reflow was determined by injection of thioflavin S at the end of reperfusion and compared with regional myocardial blood flow (RMBF; radioactive microspheres) and infarct size (triphenyltetrazolium). The area of no reflow progressively increased from 12.2 +/- 4.2% of the risk area after 2 min of reperfusion to 30.8 +/- 3.1% after 2 h and 34.9 +/- 3.3% after 8 h and significantly correlated with infarct size after 1 h of reperfusion (r = 0.88-0.97). This rapid expansion of no reflow predominantly occurred during the first 2 h, finally encompassing approximately 80% of the infarct size, and was accompanied by a decrease of RMBF within the risk area, being hyperemic after 2 min of reperfusion (3.78 +/- 0.75 ml x min(-1) x g(-1)) and plateauing at a level of approximately 0.9 ml x min(-1) x g(-1) by 2 and 8 h of reperfusion (preischemic RMBF: 2.06 +/- 0.01 ml x min(-1) x g(-1)). The development of macroscopic hemorrhage lagged behind no reflow, was closely correlated with it, and may be the consequence of microvascular damage.
机译：目的是确定与再灌注相关的无回流扩张的程度和时间过程。在五组麻醉的开胸兔子（30分钟的冠状动脉闭塞和不同的再灌注持续时间）中，在再灌注结束时通过注射硫代黄素S来确定解剖学上没有再流，并将其与局部心肌血流（RMBF;放射性微球）进行比较）和梗死面积（三苯基四唑）。无再流面积从再灌注2分钟后的风险区域的12.2 +/- 4.2％逐渐增加到2小时后的30.8 +/- 3.1％和8小时后的34.9 +/- 3.3％并与梗死后的梗死面积显着相关1 h再灌注（r = 0.88-0.97）。这种无血流的迅速扩大主要发生在最初的2小时内，最终占梗死面积的80％，并伴随着风险区域内的RMBF降低，再灌注2分钟后即为充血（3.78 +/- 0.75 ml x min（-1）xg（-1）），并在再灌注2和8 h时稳定在约0.9 ml x min（-1）xg（-1）的水平（缺血前RMBF：2.06 +/- 0.01 ml x min（-1）xg（-1））。宏观出血的发展滞后于无复流，与之密切相关，可能是微血管损伤的结果。

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