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首页> 外文期刊>American Journal of Physiology >Receptor mechanisms of serotonin-induced prenodal lymphatic constriction in the canine forelimb.
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Receptor mechanisms of serotonin-induced prenodal lymphatic constriction in the canine forelimb.

机译：血清素诱导犬前肢淋巴结狭窄的受体机制。

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摘要

Numerous endogenous vasoactive agents have been shown to cause lymphatic smooth muscle contraction. In this study, we assessed the ability of serotonin (5-HT) to alter lymphatic smooth muscle activity and elucidated the receptor mechanisms of 5-HT's actions. Both intralymphatic and intra-arterial administration of 5-HT significantly increased lymphatic smooth muscle activity in lymphatics perfused at constant flow, as indicated by an increase in lymphatic perfusion pressure. The 5-HT-induced increase in lymphatic perfusion pressure is attenuated but not blocked by the intra-arterial infusion of phentolamine, suggesting the involvement of alpha-adrenoreceptors and 5-HT receptors. Intralymphatic infusion of the 5-HT2-receptor-agonist alpha-methylserotonin significantly increased lymphatic perfusion pressure, either alone or when administered into an alpha-receptor blocked preparation, whereas the 5-HT1-receptor-agonist carboxyami-dotryptamine maleate did not effect the prenodal lymphatics. These data indicate that the lymphatic smooth muscle contraction produced by 5-HT is mediated both by lymphatic alpha-adrenoreceptors and 5-HT2 receptors.
机译：已经显示出多种内源性血管活性剂引起淋巴平滑肌收缩。在这项研究中，我们评估了5-羟色胺（5-HT）改变淋巴平滑肌活动的能力，并阐明了5-HT作用的受体机制。淋巴内和动脉内施用5-HT均显着增加了以恒定流量灌注的淋巴管中的淋巴平滑肌活性，如淋巴灌注压力的升高所表明。 5-HT诱导的淋巴灌注压力的升高被苯酚胺的动脉内输注减弱但未被阻断，表明α-肾上腺素受体和5-HT受体的参与。淋巴内5-HT 2-受体激动剂α-甲基5-羟色胺的输注显着增加了淋巴灌注压力，无论是单独使用还是与α-受体封闭制剂一起给药，而5-HT 1-受体激动剂羧酰胺-多巴酚丁胺对马来酸盐均无影响。淋巴结肿大。这些数据表明由5-HT产生的淋巴平滑肌收缩是由淋巴α-肾上腺素受体和5-HT 2受体介导的。

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