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首页> 外文期刊>American Journal of Physiology >Effects of aging on the cardiac remodeling induced by chronic high-altitude hypoxia in rat.
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Effects of aging on the cardiac remodeling induced by chronic high-altitude hypoxia in rat.

机译：衰老对慢性高海拔缺氧所致大鼠心脏重构的影响。

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摘要

Effects of chronic high-altitude hypoxia on the remodeling of right ventricle were examined in three age groups of rats: 2, 6, and 18 mo. The extent of right ventricular (RV) hypertrophy (RVH) showed an age-associated diminution. RV cell size and pericellular fibrosis showed a significant increase in the 2- and 6-mo-old exposed rats but not in the 18-mo-old exposed rats compared with control. A hyperplasic response was underscored in the three exposed age groups but appeared less pronounced in the 18-mo-old rats. A significant decrease in the transient outward potassium current (Ito) density was observed in RV cell only in the 2-mo-old exposed group compared with the control group. In the control group, there was a clear tendency for Ito density to decrease as a function of age. The sustained outward current density was modified neither by the hypoxia condition nor by the age. Neither the cytochrome c oxidase activity nor the heat shock protein 72 content in the RV was altered after hypoxic exposure regardless of age. The norepinephrine content in the RV was significantly decreased in each age group exposed to hypoxia when compared with their age-matched control group. Our findings indicate that the remodeling (at morphological and electrophysiological levels) induced by chronic hypoxia in the RV can be decreased by the natural aging process.
机译：在3、2、6和18 mo的三个年龄组中，研究了慢性高原低氧对右心室重构的影响。右心室肥大程度与年龄相关。与对照组相比，暴露于2个月和6个月大的大鼠中RV细胞的大小和周围细胞纤维化显着增加，而暴露于18个月大的大鼠中则没有。在三个暴露年龄组中强调了增生反应，但在18个月大的大鼠中似乎不太明显。与对照组相比，仅在暴露于2 mo的暴露组中，在RV细胞中观察到瞬时外向钾电流（Ito）密度显着降低。在对照组中，有明显的趋势，即伊托密度随年龄而降低。持续的向外电流密度既不会因缺氧条件也不会因年龄而改变。缺氧暴露后，无论年龄如何，RV中的细胞色素c氧化酶活性和热休克蛋白72含量均未改变。与年龄匹配的对照组相比，每个处于低氧状态的年龄组的RV中去甲肾上腺素含量均显着降低。我们的研究结果表明，自然衰老过程可以减少由RV慢性缺氧引起的重塑（在形态和电生理水平）。

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