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首页> 外文期刊>American Journal of Physiology >Association between airway hyperreactivity and bronchial macrophage dysfunction in individuals with mild asthma.
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Association between airway hyperreactivity and bronchial macrophage dysfunction in individuals with mild asthma.

机译：轻度哮喘患者气道反应过度与支气管巨噬细胞功能障碍之间的关联。

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摘要

Little is known about the functional capabilities of bronchial macrophages (BMs) and their relationship to airway disease such as asthma. We hypothesize that BMs from asthmatics may be modulated in their function compared with similar cells from healthy individuals. BMs obtained by induced sputum from mild asthmatics (n = 20) and healthy individuals (n = 20) were analyzed using flow cytometry for CD16, CD64, CD11b, CD14, and human leukocyte antigen-DR expression, phagocytosis of IgG opsonized yeast, and oxidant production. Asthma status was assessed by lung function [percent predicted forced vital capacity and forced expiratory volume in 1 s (FEV(1))], percent sputum eosinophils, and nonspecific airway responsiveness [provocative concentration that produces a 20% fall in FEV(1) (PC(20,FEV1))]. Asthmatics with >5% airway eosinophils (AEo+) had decreased BM CD64 expression and phagocytosis compared with asthmatics with <5% eosinophils (AEo-). Among asthmatics, a significant correlation was found between CD64 expression and BM phagocytosis (R = 0.7, P < 0.009). Phagocytosis was also correlated with PC(20,FEV1) (R = 0.6, P < 0.007), lung function (%predicted FEV(1), R = 0.7, P < 0.002) and percent eosinophils (R = -0.6, P < 0.01). In conclusion, BM from asthmatics are functionally modulated, possibly by Th2 cytokines involved in asthma pathology.
机译：对于支气管巨噬细胞（BMs）的功能能力及其与气道疾病（例如哮喘）的关系知之甚少。我们假设与健康个体的相似细胞相比，哮喘患者的BMs的功能可能受到调节。使用流式细胞仪分析了从轻度哮喘患者（n = 20）和健康个体（n = 20）的痰液中获得的BMs的CD16，CD64，CD11b，CD14和人白细胞抗原DR的表达，IgG调理酵母的吞噬作用，以及氧化剂的产生。通过肺功能[预测的肺活量百分比和1秒内的强制呼气量百分比（FEV（1））]，痰中的嗜酸性粒细胞百分比和非特异性气道反应性[引起肺炎的FEV下降20％的刺激性浓度]评估哮喘状态。 （PC（20，FEV1））]。与哮喘患者的<5％嗜酸性粒细胞（AEo-）相比，气道> 5％嗜酸性粒细胞（AEo +）的哮喘患者的BM CD64表达和吞噬能力降低。在哮喘患者中，发现CD64表达与BM吞噬作用之间存在显着相关性（R = 0.7，P <0.009）。吞噬作用还与PC（20，FEV1）（R = 0.6，P <0.007），肺功能（预测的FEV（1）％，R = 0.7，P <0.002）和嗜酸性粒细胞百分比（R = -0.6，P < 0.01）。总之，哮喘患者的BM可能受到哮喘病理中涉及的Th2细胞因子的功能调节。

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