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首页> 外文期刊>American Journal of Physiology >Ca(2+)-activated K(+) channels modulate basal and E(2)beta-induced rises in uterine blood flow in ovine pregnancy.
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Ca(2+)-activated K(+) channels modulate basal and E(2)beta-induced rises in uterine blood flow in ovine pregnancy.

机译：Ca（2+）激活K（+）通道调节绵羊妊娠中子宫血流的基础和E（2）β诱导的子宫上升。

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摘要

Uterine blood flow (UBF) increases >30-fold during ovine pregnancy. During the last trimester, this reflects vasodilation, which may be due to placentally derived estrogens. In nonpregnant ewes, estradiol-17 beta (E(2)beta) increases UBF >10-fold by activating nitric oxide synthase and large conductance calcium-dependent potassium channels (BK(Ca)). To determine whether BK(Ca) channels modulate basal and E(2)beta-induced increases in UBF, studies were performed in near-term pregnant ewes with uterine artery flow probes and catheters for intra-arterial infusions of tetraethylammonium (TEA), a selective BK(Ca) channel antagonist at <1 mM, in the absence or presence of E(2)beta (1 microg/kg iv). Uterine arteries were collected to measure BK(Ca) channel mRNA. TEA (0.15 mM) decreased basal UBF (P < 0.0001) 40 +/- 8% and 55 +/- 7% (n = 11) at 60 and 90 min, respectively, and increased resistance 175 +/- 48% without affecting (P > 0.1) mean arterial pressure (MAP), heart rate, or contralateral UBF. Systemic E(2)beta increased UBF 30 +/- 6% and heart rate 13 +/- 1% (P < or 0.0001, n E(2)beta-induced increases in UBF without affecting increases in heart rate (10 +/- 4%; P = 0.006). BK(Ca) channel mRNA was present in uterine artery myocytes from pregnant and nonpregnant ewes. Exponential increases in ovine UBF in late pregnancy may reflect BK(Ca) channel activation, which may be mediated by placentally derived estrogens.
机译：绵羊怀孕期间子宫血流量（UBF）增加> 30倍。在最后三个月中，这反映出血管扩张，这可能是由于胎盘来源的雌激素引起的。在非妊娠母羊中，雌二醇-17 beta（E（2）beta）通过激活一氧化氮合酶和大电导钙依赖性钾通道（BK（Ca））使UBF> 10倍。为了确定BK（Ca）通道是否能调节基底和E（2）β诱导的UBF的增加，在近期妊娠母羊中进行了子宫动脉血流探头和导管的动脉内四乙基铵（TEA）输注的研究。选择性BK（Ca）通道拮抗剂，<1 mM，不存在或存在E（2）beta（1 microg / kg iv）。收集子宫动脉以测量BK（Ca）通道mRNA。 TEA（0.15 mM）分别在60和90分钟时降低了基础UBF（P <0.0001）40 +/- 8％和55 +/- 7％（n = 11），并且在不影响的情况下增加了175 +/- 48％的抵抗力（P> 0.1）平均动脉压（MAP），心率或对侧UBF。全身性E（2）β使UBF增加30 +/- 6％，心率增加13 +/- 1％（P <或0.0001，n E（2）β诱导的UBF增加而不会影响心率的增加（10 + / -4％; P = 0.006）。怀孕和未怀孕母羊的子宫动脉心肌细胞中均存在BK（Ca）通道mRNA。妊娠晚期绵羊UBF的指数增加可能反映了BK（Ca）通道激活，这可能是胎盘介导的衍生雌激素。

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