Identified neurons in C. elegans coexpress vesicular transporters for acetylcholine and monoamines.

Duerr JS; Gaskin J; Rand JB

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Identified neurons in C. elegans coexpress vesicular transporters for acetylcholine and monoamines.

机译：秀丽隐杆线虫中鉴定出的神经元共表达乙酰胆碱和单胺的囊泡转运蛋白。

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We have identified four neurons (VC4, VC5, HSNL, HSNR) in Caenorhabditis elegans adult hermaphrodites that express both the vesicular acetylcholine transporter and the vesicular monoamine transporter. All four of these cells are motor neurons that innervate the egg-laying muscles of the vulva. In addition, they all express choline acetyltransferase, the synthetic enzyme for acetylcholine. The distributions of the vesicular acetylcholine transporter and the vesicular monoamine transporter are not identical within the individual cells. In mutants deficient for either of these transporters, there is no apparent compensatory change in the expression of the remaining transporter. This is the first report of neurons that express two different vesicular neurotransmitter transporters in vivo.

机译：我们在秀丽隐杆线虫成年雌雄同体中确定了四个神经元（VC4，VC5，HSNL，HSNR），它们表达了水泡乙酰胆碱转运蛋白和水泡单胺转运蛋白。所有这四个细胞都是运动神经元，可支配外阴产卵的肌肉。此外，它们都表达胆碱乙酰基转移酶，即胆碱的合成酶。在单个细胞中，水泡乙酰胆碱转运蛋白和水泡单胺转运蛋白的分布不同。在缺乏这些转运蛋白的突变体中，其余转运蛋白的表达没有明显的补偿性变化。这是神经元在体内表达两种不同的水泡神经递质转运蛋白的首次报道。

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《American Journal of Physiology》 |2001年第6期|共7页
作者
Duerr JS; Gaskin J; Rand JB;
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正文语种 eng
中图分类人体生理学;
关键词
Carrier Proteins; Membrane Glycoproteins; Membrane Transport Proteins; Neurons; 载体蛋白质类; 膜糖蛋白类; 神经元; 神经肽类; 突触小泡;

机译：Carrier Proteins;Membrane Glycoproteins;Membrane Transport Proteins;Neurons;载体蛋白质类;膜糖蛋白类;神经元;神经肽类;突触小泡;

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1. Identified neurons in C. elegans coexpress vesicular transporters for acetylcholine and monoamines. [J] . Duerr JS, Gaskin J, Rand JB American Journal of Physiology . 2001,第6期

机译：秀丽隐杆线虫中鉴定出的神经元共表达乙酰胆碱和单胺的囊泡转运蛋白。
2. A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. [J] . Sandoval GM, Duerr JS, Hodgkin J, Nature neuroscience . 2006,第5期

机译：秀丽隐杆线虫中的囊泡乙酰胆碱转运蛋白VAChT / UNC-17和突触素/ SNB-1之间的遗传相互作用。
3. Genetic labeling of both the axons of transduced, glutamatergic neurons in rat postrhinal cortex and their postsynaptic neurons in other neocortical areas by Herpes Simplex Virus vectors that coexpress an axon-targeted beta-galactosidase and wheat germ agglutinin from a vesicular glutamate transporter-1 promoter. [J] . Zhang GR, Cao H, Li X, Brain research . 2010,第Null期

机译：通过单纯疱疹病毒载体对大鼠轴后皮层中转导的谷氨酸能神经元的轴突和其他新皮质区域中突触后神经元的轴突进行遗传标记，这些病毒载体可通过水泡谷氨酸转运蛋白-1启动子共表达轴突靶向的β-半乳糖苷酶和小麦胚芽凝集素。
4. Neuron matching in C. elegans with robust approximate linear regression without correspondence [C] . Amin Nejatbakhsh, Erdem Varol IEEE Winter Conference on Applications of Computer Vision . 2021

机译：Neuron匹配在C.杆杆线上，具有强大的近似线性回归而没有通信
5. Investigation of ligand binding sites in vesicular acetylcholine transporter. [D] . Khare, Parul. 2009

机译：囊泡乙酰胆碱转运蛋白中配体结合位点的研究。
6. Genetic labeling of both the axons of transduced glutamatergic neurons in rat postrhinal cortex and their postsynaptic neurons in other neocortical areas by Herpes Simplex Virus vectors that coexpress an axon-targeted ß-galactosidase and wheat germ agglutinin from a vesicular glutamate transporter-1 promoter [O] . Guo-rong Zhang, Haiyan Cao, Xu Li, -1

机译：通过疱疹病毒载体在其他新奇地区癌症术中的转导谷氨酸神经元轴突的遗传标记及其在其他新生地区中的突出病毒载体中的含有来自囊泡谷氨酸转运蛋白转运蛋白-1启动子的轴突靶向β-半乳糖苷酶和小麦胚芽凝集素
7. Genetic labeling of both the axons of transduced, glutamatergic neurons in rat postrhinal cortex and their postsynaptic neurons in other neocortical areas by Herpes Simplex Virus vectors that coexpress an axon-targeted β-galactosidase and wheat germ agglutinin from a vesicular glutamate transporter-1 promoter [O] . Guo-rong Zhang, Haiyan Cao, Xu Li, 2010

机译：通过疱疹病毒载体在其他新奇地区癌症脊髓型皮层及其突触后神经元的遗传标记及其在其他新生地区的突触后神经元中的疱疹病毒载体，从囊泡谷氨酸转运蛋白转运蛋白中共同抑制轴突靶向β-半乳糖苷酶和小麦胚芽凝集素

Identified neurons in C. elegans coexpress vesicular transporters for acetylcholine and monoamines.

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